Concurrent Infantile Hemangioendothelioma and Mesenchymal Hamartoma in a Developmentally Arrested Liver of an Infant Requiring Hepatic Transplantation

Pablo A. Bejarano, Maria F. Serrano, Victor Casillas, Louis P. Dehner, Tomoaki Kato, Naveen Mittal, Maria Rodriguez, Andreas Tzakis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A newborn female underwent a surgical resection for a hepatic mass discovered prenatally by ultrasonography, and diagnosed pathologically as a mesenchymal hamartoma. Within 4 months after surgery, multiple cutaneous hemangiomas developed and a multinodular mass was detected in the liver. A liver biopsy showed an infantile hemangioendothelioma with type I features. An orthotopic liver transplant was performed due to the extensive nature of the hepatic involvement and progressive respiratory compromise. Virtually the entire liver was involved by a large infantile hemangioendothelioma. A multicystic mesenchymal hamartoma was also found on the left side. In addition, the uninvolved hepatic parenchyma had features recapitulating the fetal liver. This simultaneous involvement of the liver by a mesenchymal hamartoma and infantile hemangioendothelioma is unique. A review of the literature revealed only one incompletely characterized case with similar findings.

Original languageEnglish
Pages (from-to)552-557
Number of pages6
JournalPediatric and Developmental Pathology
Volume6
Issue number6
StatePublished - Nov 1 2003

Fingerprint

Hemangioendothelioma
Hamartoma
Liver Transplantation
Liver
Dermatologic Surgical Procedures
Hemangioma
Ultrasonography
Newborn Infant
Transplants
Biopsy

Keywords

  • Alpha-fetoprotein
  • Dysmorphism
  • Infantile hemangioendothelioma
  • Liver
  • Mesenchymal hamartoma
  • Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Concurrent Infantile Hemangioendothelioma and Mesenchymal Hamartoma in a Developmentally Arrested Liver of an Infant Requiring Hepatic Transplantation. / Bejarano, Pablo A.; Serrano, Maria F.; Casillas, Victor; Dehner, Louis P.; Kato, Tomoaki; Mittal, Naveen; Rodriguez, Maria; Tzakis, Andreas.

In: Pediatric and Developmental Pathology, Vol. 6, No. 6, 01.11.2003, p. 552-557.

Research output: Contribution to journalArticle

Bejarano, Pablo A. ; Serrano, Maria F. ; Casillas, Victor ; Dehner, Louis P. ; Kato, Tomoaki ; Mittal, Naveen ; Rodriguez, Maria ; Tzakis, Andreas. / Concurrent Infantile Hemangioendothelioma and Mesenchymal Hamartoma in a Developmentally Arrested Liver of an Infant Requiring Hepatic Transplantation. In: Pediatric and Developmental Pathology. 2003 ; Vol. 6, No. 6. pp. 552-557.
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