Concurrent Infantile Hemangioendothelioma and Mesenchymal Hamartoma in a Developmentally Arrested Liver of an Infant Requiring Hepatic Transplantation

Pablo A Bejarano, Maria F. Serrano, Javier Casillas, Louis P. Dehner, Tomoaki Kato, Naveen Mittal, Maria M. Rodriguez, Andreas Tzakis

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A newborn female underwent a surgical resection for a hepatic mass discovered prenatally by ultrasonography, and diagnosed pathologically as a mesenchymal hamartoma. Within 4 months after surgery, multiple cutaneous hemangiomas developed and a multinodular mass was detected in the liver. A liver biopsy showed an infantile hemangioendothelioma with type I features. An orthotopic liver transplant was performed due to the extensive nature of the hepatic involvement and progressive respiratory compromise. Virtually the entire liver was involved by a large infantile hemangioendothelioma. A multicystic mesenchymal hamartoma was also found on the left side. In addition, the uninvolved hepatic parenchyma had features recapitulating the fetal liver. This simultaneous involvement of the liver by a mesenchymal hamartoma and infantile hemangioendothelioma is unique. A review of the literature revealed only one incompletely characterized case with similar findings.

Original languageEnglish (US)
Pages (from-to)552-557
Number of pages6
JournalPediatric and Developmental Pathology
Volume6
Issue number6
DOIs
StatePublished - Jan 1 2003

Keywords

  • Alpha-fetoprotein
  • Dysmorphism
  • Infantile hemangioendothelioma
  • Liver
  • Mesenchymal hamartoma
  • Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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