Concurrent Infantile Hemangioendothelioma and Mesenchymal Hamartoma in a Developmentally Arrested Liver of an Infant Requiring Hepatic Transplantation

Pablo A. Bejarano, Maria F. Serrano, Javier Casillas, Louis P. Dehner, Tomoaki Kato, Naveen Mittal, Maria M. Rodriguez, Andreas Tzakis

Research output: Contribution to journalArticle

11 Scopus citations


A newborn female underwent a surgical resection for a hepatic mass discovered prenatally by ultrasonography, and diagnosed pathologically as a mesenchymal hamartoma. Within 4 months after surgery, multiple cutaneous hemangiomas developed and a multinodular mass was detected in the liver. A liver biopsy showed an infantile hemangioendothelioma with type I features. An orthotopic liver transplant was performed due to the extensive nature of the hepatic involvement and progressive respiratory compromise. Virtually the entire liver was involved by a large infantile hemangioendothelioma. A multicystic mesenchymal hamartoma was also found on the left side. In addition, the uninvolved hepatic parenchyma had features recapitulating the fetal liver. This simultaneous involvement of the liver by a mesenchymal hamartoma and infantile hemangioendothelioma is unique. A review of the literature revealed only one incompletely characterized case with similar findings.

Original languageEnglish (US)
Pages (from-to)552-557
Number of pages6
JournalPediatric and Developmental Pathology
Issue number6
StatePublished - Jan 1 2003



  • Alpha-fetoprotein
  • Dysmorphism
  • Infantile hemangioendothelioma
  • Liver
  • Mesenchymal hamartoma
  • Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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