Abstract
CLTA4 is relevant for FOXP3+Treg cells, and the link between skewed X chromosome inactivation (XCI) and autoimmunity is recognized. The observation of immune dysregulation polyendocrinopathy enteropathy X-linked syndrome and multiorgan endocrine autoimmune phenomena in various members of one family, associated with a CTLA4 polymorphism and skewed XCI, provides an in vivo model of how mechanisms of immune dysregulation may cooperate.
Original language | English (US) |
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Pages (from-to) | 131-134 |
Number of pages | 4 |
Journal | European Journal of Endocrinology |
Volume | 167 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2012 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology