Concomitant infections of Plasmodium falciparum and Wuchereria bancrofti on the Kenyan coast

Ephantus J. Muturi, Charles M. Mbogo, Joseph M. Mwangangi, Zipporah W. Ng'ang'a, Ephantus W. Kabiru, Charles Mwandawiro, John C Beier

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Abstract

Background: Anopheles gambiae s.l. and An. funestus are important vectors of malaria and bancroftian filariasis, which occur as co-endemic infections along the Kenyan Coast. However, little is known about the occurrence and prevalence of concomitant infections of the two diseases in mosquito and human populations in these areas. This study reports the prevalence of concomitant infections of Plasmodium falciparum and Wuchereria bancrofti in mosquito and human populations in Jilore and Shakahola villages in Malindi, Kenya. Methods: Mosquitoes were sampled inside houses by pyrethrum spray sheet collection (PSC) while blood samples were collected by finger prick technique at the end of entomological survey. Results: A total of 1,979 female Anopheles mosquitoes comprising of 1,919 Anopheles gambiae s.l and 60 An. funestus were collected. Concomitant infections of P. falciparum sporozoites and filarial worms occurred in 1.1% and 1.6% of An. gambiae s.l collected in Jilore and Shakahola villages respectively. Wuchereria-infected mosquitoes had higher sporozoite rates compared to non-infected mosquitoes, but multiple infections appeared to reduce mosquito survivorship making transmission of such infections rare. None of the persons examined in Shakahola (n = 107) had coinfections of the two parasites, whereas in Jilore (n = 94), out of the 4.3% of individuals harbouring both parasites, 1.2% had P. falciparum gametocytes and microfilariae and could potentially infect the mosquito with both parasites simultaneously. Conclusion: Concerted efforts should be made to integrate the control of malaria and bancroftian filariasis in areas where they co-exist.

Original languageEnglish
Article number8
JournalFilaria Journal
Volume5
DOIs
StatePublished - May 24 2006

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Wuchereria bancrofti
Plasmodium falciparum
Culicidae
Infection
Anopheles gambiae
Filariasis
Sporozoites
Parasites
Coinfection
Malaria
Wuchereria
Chrysanthemum cinerariifolium
Microfilariae
Anopheles
Infectious Disease Transmission
Kenya
Population
Fingers
Survival Rate
Cross-Sectional Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Muturi, E. J., Mbogo, C. M., Mwangangi, J. M., Ng'ang'a, Z. W., Kabiru, E. W., Mwandawiro, C., & Beier, J. C. (2006). Concomitant infections of Plasmodium falciparum and Wuchereria bancrofti on the Kenyan coast. Filaria Journal, 5, [8]. https://doi.org/10.1186/1475-2883-5-8

Concomitant infections of Plasmodium falciparum and Wuchereria bancrofti on the Kenyan coast. / Muturi, Ephantus J.; Mbogo, Charles M.; Mwangangi, Joseph M.; Ng'ang'a, Zipporah W.; Kabiru, Ephantus W.; Mwandawiro, Charles; Beier, John C.

In: Filaria Journal, Vol. 5, 8, 24.05.2006.

Research output: Contribution to journalArticle

Muturi EJ, Mbogo CM, Mwangangi JM, Ng'ang'a ZW, Kabiru EW, Mwandawiro C et al. Concomitant infections of Plasmodium falciparum and Wuchereria bancrofti on the Kenyan coast. Filaria Journal. 2006 May 24;5. 8. https://doi.org/10.1186/1475-2883-5-8
Muturi, Ephantus J. ; Mbogo, Charles M. ; Mwangangi, Joseph M. ; Ng'ang'a, Zipporah W. ; Kabiru, Ephantus W. ; Mwandawiro, Charles ; Beier, John C. / Concomitant infections of Plasmodium falciparum and Wuchereria bancrofti on the Kenyan coast. In: Filaria Journal. 2006 ; Vol. 5.
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abstract = "Background: Anopheles gambiae s.l. and An. funestus are important vectors of malaria and bancroftian filariasis, which occur as co-endemic infections along the Kenyan Coast. However, little is known about the occurrence and prevalence of concomitant infections of the two diseases in mosquito and human populations in these areas. This study reports the prevalence of concomitant infections of Plasmodium falciparum and Wuchereria bancrofti in mosquito and human populations in Jilore and Shakahola villages in Malindi, Kenya. Methods: Mosquitoes were sampled inside houses by pyrethrum spray sheet collection (PSC) while blood samples were collected by finger prick technique at the end of entomological survey. Results: A total of 1,979 female Anopheles mosquitoes comprising of 1,919 Anopheles gambiae s.l and 60 An. funestus were collected. Concomitant infections of P. falciparum sporozoites and filarial worms occurred in 1.1{\%} and 1.6{\%} of An. gambiae s.l collected in Jilore and Shakahola villages respectively. Wuchereria-infected mosquitoes had higher sporozoite rates compared to non-infected mosquitoes, but multiple infections appeared to reduce mosquito survivorship making transmission of such infections rare. None of the persons examined in Shakahola (n = 107) had coinfections of the two parasites, whereas in Jilore (n = 94), out of the 4.3{\%} of individuals harbouring both parasites, 1.2{\%} had P. falciparum gametocytes and microfilariae and could potentially infect the mosquito with both parasites simultaneously. Conclusion: Concerted efforts should be made to integrate the control of malaria and bancroftian filariasis in areas where they co-exist.",
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AB - Background: Anopheles gambiae s.l. and An. funestus are important vectors of malaria and bancroftian filariasis, which occur as co-endemic infections along the Kenyan Coast. However, little is known about the occurrence and prevalence of concomitant infections of the two diseases in mosquito and human populations in these areas. This study reports the prevalence of concomitant infections of Plasmodium falciparum and Wuchereria bancrofti in mosquito and human populations in Jilore and Shakahola villages in Malindi, Kenya. Methods: Mosquitoes were sampled inside houses by pyrethrum spray sheet collection (PSC) while blood samples were collected by finger prick technique at the end of entomological survey. Results: A total of 1,979 female Anopheles mosquitoes comprising of 1,919 Anopheles gambiae s.l and 60 An. funestus were collected. Concomitant infections of P. falciparum sporozoites and filarial worms occurred in 1.1% and 1.6% of An. gambiae s.l collected in Jilore and Shakahola villages respectively. Wuchereria-infected mosquitoes had higher sporozoite rates compared to non-infected mosquitoes, but multiple infections appeared to reduce mosquito survivorship making transmission of such infections rare. None of the persons examined in Shakahola (n = 107) had coinfections of the two parasites, whereas in Jilore (n = 94), out of the 4.3% of individuals harbouring both parasites, 1.2% had P. falciparum gametocytes and microfilariae and could potentially infect the mosquito with both parasites simultaneously. Conclusion: Concerted efforts should be made to integrate the control of malaria and bancroftian filariasis in areas where they co-exist.

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