Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease

Mary E. Harper; Mark H. Kaplan; Lisa M. Marselle; Savita G. Pahwa; Karen J. Chayt; M. G. Sarngadharan; Flossie Wong-Staal; Robert C. Gallo

doi:10.1056/NEJM198610233151707

Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease

Mary E. Harper, Mark H. Kaplan, Lisa M. Marselle, Savita G. Pahwa, Karen J. Chayt, M. G. Sarngadharan, Flossie Wong-Staal, Robert C. Gallo

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

All currently known human retroviruses are T-cell lymphotropic viruses (HTLVs) and primarily infect T₄ cells (reviewed by Wong-Staal and Gallo¹). HTLV-I immortalizes normal T lymphocytes in vitro, and in vivo is associated with adult T-cell leukemia/lymphoma² ³ ⁴ ⁵ as well as other T₄ neoplasms with various clinicopathological names.⁶ HTLV-II also transforms T₄ cells, but has been detected only rarely in milder forms of leukemia⁷ (and Salahuddin Z, Gallo RC: unpublished data). In contrast, HTLV-III (human immunodeficiency virus) is cytopathic to its target T₄ cell and is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).⁸ ⁹ ¹⁰ ¹¹ ¹² HTLV-IV, more.

Original language	English (US)
Pages (from-to)	1073-1078
Number of pages	6
Journal	New England Journal of Medicine
Volume	315
Issue number	17
DOIs	https://doi.org/10.1056/NEJM198610233151707
State	Published - Oct 23 1986
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease. / Harper, Mary E.; Kaplan, Mark H.; Marselle, Lisa M.; Pahwa, Savita G.; Chayt, Karen J.; Sarngadharan, M. G.; Wong-Staal, Flossie; Gallo, Robert C.

In: New England Journal of Medicine, Vol. 315, No. 17, 23.10.1986, p. 1073-1078.

Research output: Contribution to journal › Article › peer-review

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title = "Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease",

abstract = "All currently known human retroviruses are T-cell lymphotropic viruses (HTLVs) and primarily infect T4 cells (reviewed by Wong-Staal and Gallo1). HTLV-I immortalizes normal T lymphocytes in vitro, and in vivo is associated with adult T-cell leukemia/lymphoma2 3 4 5 as well as other T4 neoplasms with various clinicopathological names.6 HTLV-II also transforms T4 cells, but has been detected only rarely in milder forms of leukemia7 (and Salahuddin Z, Gallo RC: unpublished data). In contrast, HTLV-III (human immunodeficiency virus) is cytopathic to its target T4 cell and is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).8 9 10 11 12 HTLV-IV, more.",

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AU - Harper, Mary E.

AU - Kaplan, Mark H.

AU - Marselle, Lisa M.

AU - Pahwa, Savita G.

AU - Chayt, Karen J.

AU - Sarngadharan, M. G.

AU - Wong-Staal, Flossie

AU - Gallo, Robert C.

PY - 1986/10/23

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AB - All currently known human retroviruses are T-cell lymphotropic viruses (HTLVs) and primarily infect T4 cells (reviewed by Wong-Staal and Gallo1). HTLV-I immortalizes normal T lymphocytes in vitro, and in vivo is associated with adult T-cell leukemia/lymphoma2 3 4 5 as well as other T4 neoplasms with various clinicopathological names.6 HTLV-II also transforms T4 cells, but has been detected only rarely in milder forms of leukemia7 (and Salahuddin Z, Gallo RC: unpublished data). In contrast, HTLV-III (human immunodeficiency virus) is cytopathic to its target T4 cell and is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).8 9 10 11 12 HTLV-IV, more.

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