Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease

Mary E. Harper, Mark H. Kaplan, Lisa M. Marselle, Savita G. Pahwa, Karen J. Chayt, M. G. Sarngadharan, Flossie Wong-Staal, Robert C. Gallo

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

All currently known human retroviruses are T-cell lymphotropic viruses (HTLVs) and primarily infect T4 cells (reviewed by Wong-Staal and Gallo1). HTLV-I immortalizes normal T lymphocytes in vitro, and in vivo is associated with adult T-cell leukemia/lymphoma2 3 4 5 as well as other T4 neoplasms with various clinicopathological names.6 HTLV-II also transforms T4 cells, but has been detected only rarely in milder forms of leukemia7 (and Salahuddin Z, Gallo RC: unpublished data). In contrast, HTLV-III (human immunodeficiency virus) is cytopathic to its target T4 cell and is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).8 9 10 11 12 HTLV-IV, more.

Original languageEnglish (US)
Pages (from-to)1073-1078
Number of pages6
JournalNew England Journal of Medicine
Volume315
Issue number17
DOIs
StatePublished - Oct 23 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease'. Together they form a unique fingerprint.

Cite this