Abstract
All currently known human retroviruses are T-cell lymphotropic viruses (HTLVs) and primarily infect T4 cells (reviewed by Wong-Staal and Gallo1). HTLV-I immortalizes normal T lymphocytes in vitro, and in vivo is associated with adult T-cell leukemia/lymphoma2 3 4 5 as well as other T4 neoplasms with various clinicopathological names.6 HTLV-II also transforms T4 cells, but has been detected only rarely in milder forms of leukemia7 (and Salahuddin Z, Gallo RC: unpublished data). In contrast, HTLV-III (human immunodeficiency virus) is cytopathic to its target T4 cell and is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).8 9 10 11 12 HTLV-IV, more.
Original language | English (US) |
---|---|
Pages (from-to) | 1073-1078 |
Number of pages | 6 |
Journal | New England Journal of Medicine |
Volume | 315 |
Issue number | 17 |
DOIs | |
State | Published - Oct 23 1986 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)