Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease

Mary E. Harper, Mark H. Kaplan, Lisa M. Marselle, Savita G. Pahwa, Karen J. Chayt, M. G. Sarngadharan, Flossie Wong-Staal, Robert C. Gallo

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Abstract

All currently known human retroviruses are T-cell lymphotropic viruses (HTLVs) and primarily infect T4 cells (reviewed by Wong-Staal and Gallo1). HTLV-I immortalizes normal T lymphocytes in vitro, and in vivo is associated with adult T-cell leukemia/lymphoma2 3 4 5 as well as other T4 neoplasms with various clinicopathological names.6 HTLV-II also transforms T4 cells, but has been detected only rarely in milder forms of leukemia7 (and Salahuddin Z, Gallo RC: unpublished data). In contrast, HTLV-III (human immunodeficiency virus) is cytopathic to its target T4 cell and is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).8 9 10 11 12 HTLV-IV, more.

Original languageEnglish (US)
Pages (from-to)1073-1078
Number of pages6
JournalNew England Journal of Medicine
Volume315
Issue number17
DOIs
StatePublished - Oct 23 1986

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ASJC Scopus subject areas

  • Medicine(all)

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Harper, M. E., Kaplan, M. H., Marselle, L. M., Pahwa, S. G., Chayt, K. J., Sarngadharan, M. G., Wong-Staal, F., & Gallo, R. C. (1986). Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease. New England Journal of Medicine, 315(17), 1073-1078. https://doi.org/10.1056/NEJM198610233151707