Concise Review: The Deleterious Effects of Cigarette Smoking and Nicotine Usage and Mesenchymal Stem Cell Function and Implications for Cell-Based Therapies

Jordan M. Greenberg, Carlos M. Carballosa, Herman S Cheung

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Stem cell sources for cell-based therapeutics are often screened for infectious agents and genetic diseases prior to implantation; however, there are other risk factors that are often overlooked, which may ultimately lead to less efficacious clinical outcomes. One such risk factor is exposure of mesenchymal stem cells (MSCs) to cigarette smoke or nicotine. Recent data have shown that exposure to cigarette smoke or nicotine leads to decreased regenerative potential, namely decreased proliferation, decreased migration, and decreased differentiation potential of exposed MSCs. This review provides a brief introduction into MSCs and their respective niches and a summary regarding the interactions of cigarettes and nicotine with MSCs populations. Specifically, the effects of cigarette smoke and nicotine on the regenerative potential of MSCs (i.e., proliferation, migration, and differentiation) will be covered with an emphasis on considerations for the development of future cell-based clinical trials and therapies. Stem Cells Translational Medicine 2017;6:1815–1821.

Original languageEnglish (US)
Pages (from-to)1815-1821
Number of pages7
JournalStem cells translational medicine
Volume6
Issue number9
DOIs
StatePublished - Sep 1 2017

Keywords

  • Cell-based and tissue-based therapy
  • Electronic cigarettes
  • Mesenchymal stem cells
  • Nicotine
  • Tobacco products

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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