Serum concentration of uric acid were measured in 45 normal mother-infant pairs. At the time of delivery concentrations in mother and baby were highly significantly correlated and the cord to maternal ratio was 1.08. In the mothers, the serum concentrations rose significantly by 12 to 24 hours post partum. In the infants they also rose significantly by 12 to 24 hours, falling thereafter to a steady state after 3 days of life. Serum concentrations of uric acid in 98 normal infants could best be described by a quadriatic relationship. The data obtained provide a base for the detection of disorders of purine metabolism in infants and indicate that testing should be done after 3 days of life. The maternal-infant interrelationships observed and the course of time-related changes are important for an understanding of purine metabolism in this period.
ASJC Scopus subject areas
- Obstetrics and Gynecology