Computerized data analysis of amino acids in physiologic fluids

James H. Brown; Sherry Walker; Leah Casto; R. Rodney Howell

doi:10.1016/S0021-9673(00)89900-8

Computerized data analysis of amino acids in physiologic fluids

James H. Brown, Sherry Walker, Leah Casto, R. Rodney Howell

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A Fortran IV computer program is described which identifies, computes, and statistically evaluates amino acid concentrations determined by an automatic amino acid analyzer in physiologic fluids. The program accepts retention time and integrated peak areas from two calibration standards for identification and computational reference. Two internal standards are used to compensate for variations in injector performance and ninhydrin decay. Calibration standard responses are statistically treated to assist in detection of equipment malfunction. The statistical data base is automatically expanded through inclusion of data from normal patients. Amino acid concentrations are printed with appropriate mean and standard deviation values in a format acceptable as a final report.

Original language	English (US)
Pages (from-to)	293-304
Number of pages	12
Journal	Journal of Chromatography A
Volume	116
Issue number	2
DOIs	https://doi.org/10.1016/S0021-9673(00)89900-8
State	Published - Jan 21 1976
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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@article{a71db88152c54fb689a9f49c64b8a1d5,

title = "Computerized data analysis of amino acids in physiologic fluids",

abstract = "A Fortran IV computer program is described which identifies, computes, and statistically evaluates amino acid concentrations determined by an automatic amino acid analyzer in physiologic fluids. The program accepts retention time and integrated peak areas from two calibration standards for identification and computational reference. Two internal standards are used to compensate for variations in injector performance and ninhydrin decay. Calibration standard responses are statistically treated to assist in detection of equipment malfunction. The statistical data base is automatically expanded through inclusion of data from normal patients. Amino acid concentrations are printed with appropriate mean and standard deviation values in a format acceptable as a final report.",

author = "Brown, {James H.} and Sherry Walker and Leah Casto and Howell, {R. Rodney}",

note = "Funding Information: part by Genetics Center Grant No. C&f 19513 from the National Mzdicai Scienzs, National Institutes of Health. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1976",

month = jan,

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doi = "10.1016/S0021-9673(00)89900-8",

language = "English (US)",

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pages = "293--304",

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T1 - Computerized data analysis of amino acids in physiologic fluids

AU - Brown, James H.

AU - Walker, Sherry

AU - Casto, Leah

AU - Howell, R. Rodney

PY - 1976/1/21

Y1 - 1976/1/21

N2 - A Fortran IV computer program is described which identifies, computes, and statistically evaluates amino acid concentrations determined by an automatic amino acid analyzer in physiologic fluids. The program accepts retention time and integrated peak areas from two calibration standards for identification and computational reference. Two internal standards are used to compensate for variations in injector performance and ninhydrin decay. Calibration standard responses are statistically treated to assist in detection of equipment malfunction. The statistical data base is automatically expanded through inclusion of data from normal patients. Amino acid concentrations are printed with appropriate mean and standard deviation values in a format acceptable as a final report.

AB - A Fortran IV computer program is described which identifies, computes, and statistically evaluates amino acid concentrations determined by an automatic amino acid analyzer in physiologic fluids. The program accepts retention time and integrated peak areas from two calibration standards for identification and computational reference. Two internal standards are used to compensate for variations in injector performance and ninhydrin decay. Calibration standard responses are statistically treated to assist in detection of equipment malfunction. The statistical data base is automatically expanded through inclusion of data from normal patients. Amino acid concentrations are printed with appropriate mean and standard deviation values in a format acceptable as a final report.

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JO - Journal of Chromatography A

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