Computerised analysis of liver texture with correlation to needle biopsy

Diana Gaitini, M. Lederman, Y. Baruch, Eduard Ghersin, E. Veitsman, H. Kerner, B. Shalem, G. Yaniv, C. Sarfaty, H. Azhari

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Aim: To assist in tissue characterisation for the non-invasive diagnosis of diffuse fatty liver infiltration by providing quantitative indices of ultrasonic (US) backscatter with correlation to histology. Methods and Materials: US images from patients referred to US-guided liver needle biopsy (LNB) for persistently elevated liver enzymes or serologically positive markers for viral hepatitis were recorded. The histopathological reports were reviewed. Steatosis, inflammation and degree of fibrosis were scored from 0 (normal) to 3 (severe). Patients with level 3 steatosis without inflammation or fibrosis were selected. US images from twenty-four healthy subjects served as control. Four textural indices were calculated for a selected ROI corresponding to the biopsy site. Sensitivity and specificity of discrimination between the two groups were evaluated. Results: Fatty and healthy livers formed two distinct clusters. However, in all parametric sub-spaces there was a slight overlap between the groups with a few numbers of cases located across the dichotomy line. The sensitivity for all the indices was high (90-100%). The specificity for each of the indices was moderate. The co-occurrence local homogeneity index yielded the highest specificity (88.5%), with a sensitivity equivalent to two of the other indices (90%). Conclusions: Highly accurate "ultrasonic biopsy· may be obtained for severe fatty liver. The described indices can serve as a tool in US computer- aided diagnosis (CAD) of diffuse parenchymal liver disease, in particular for severe steatosis of the liver.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalUltraschall in der Medizin
Volume26
Issue number3
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

Fingerprint

Needle Biopsy
liver
Ultrasonics
needles
textures
Fatty Liver
ultrasonics
Liver
fibrosis
Fibrosis
sensitivity
Inflammation
Biopsy
hepatitis
dichotomies
histology
Hepatitis
infiltration
Liver Diseases
Histology

Keywords

  • Diffuse liver disease
  • Needle biopsy
  • Steatosis
  • Texture
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

Gaitini, D., Lederman, M., Baruch, Y., Ghersin, E., Veitsman, E., Kerner, H., ... Azhari, H. (2005). Computerised analysis of liver texture with correlation to needle biopsy. Ultraschall in der Medizin, 26(3), 197-202. https://doi.org/10.1055/s-2005-858267

Computerised analysis of liver texture with correlation to needle biopsy. / Gaitini, Diana; Lederman, M.; Baruch, Y.; Ghersin, Eduard; Veitsman, E.; Kerner, H.; Shalem, B.; Yaniv, G.; Sarfaty, C.; Azhari, H.

In: Ultraschall in der Medizin, Vol. 26, No. 3, 01.06.2005, p. 197-202.

Research output: Contribution to journalArticle

Gaitini, D, Lederman, M, Baruch, Y, Ghersin, E, Veitsman, E, Kerner, H, Shalem, B, Yaniv, G, Sarfaty, C & Azhari, H 2005, 'Computerised analysis of liver texture with correlation to needle biopsy', Ultraschall in der Medizin, vol. 26, no. 3, pp. 197-202. https://doi.org/10.1055/s-2005-858267
Gaitini, Diana ; Lederman, M. ; Baruch, Y. ; Ghersin, Eduard ; Veitsman, E. ; Kerner, H. ; Shalem, B. ; Yaniv, G. ; Sarfaty, C. ; Azhari, H. / Computerised analysis of liver texture with correlation to needle biopsy. In: Ultraschall in der Medizin. 2005 ; Vol. 26, No. 3. pp. 197-202.
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