Computational large-scale mapping of protein-protein interactions using structural complexes

Benjamin Shoemaker, Stefan Wuchty, Anna R. Panchenko

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Although the identification of protein interactions by high-throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein-protein or gene-gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation.

Original languageEnglish (US)
Article number3.9
JournalCurrent Protocols in Protein Science
Issue numberSUPPL.73
StatePublished - 2013
Externally publishedYes


  • Binding interface
  • IBIS
  • Inferred biomolecular interactions server
  • Protein interaction
  • Structural complex

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry


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