Computational large-scale mapping of protein-protein interactions using structural complexes

Benjamin Shoemaker, Stefan Wuchty, Anna R. Panchenko

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Although the identification of protein interactions by high-throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein-protein or gene-gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation.

Original languageEnglish (US)
Article number3.9
JournalCurrent Protocols in Protein Science
Issue numberSUPPL.73
DOIs
StatePublished - 2013

Keywords

  • Binding interface
  • IBIS
  • Inferred biomolecular interactions server
  • Protein interaction
  • Structural complex

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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