Abstract
Although the identification of protein interactions by high-throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein-protein or gene-gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation.
Original language | English (US) |
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Article number | 3.9 |
Journal | Current Protocols in Protein Science |
Issue number | SUPPL.73 |
DOIs | |
State | Published - 2013 |
Keywords
- Binding interface
- IBIS
- Inferred biomolecular interactions server
- Protein interaction
- Structural complex
ASJC Scopus subject areas
- Structural Biology
- Biochemistry