Compression-induced brain edema: Modification by prior depletion and supplementation of vitamin E

S. Yoshida, R. Busto, Myron Ginsberg, K. Abe, E. Martinez, B. D. Watson, P. Scheinberg

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We studied the degree of edema resulting from focal brain compression in rats raised on vitamin E-deficient, -normal, or -supplemented diets. After release of 24 hours of epidural compression, edema developed ipsilaterally and was characterized by extravasation of serum protein, increased water and sodium content, and little change in potassium. The degree of swelling and increase of sodium in the previously compressed area were most pronounced in the vitamin E-deficient group and mildest in the vitamin E-supplemented group. Degradative processes of biomembranes seem to participate in the pathogenesis in the pathogenesis of brain edema; vitamin E may stabilize membranes by physicochemical interactions between the phytyl side chain and polyunsaturated phospholipids, or vitamin E may disrupt chains of free radical reactions.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalNeurology
Volume33
Issue number2
StatePublished - Apr 7 1983

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Brain Edema
Vitamin E
Edema
Sodium
Free Radicals
Blood Proteins
Phospholipids
Potassium
Diet
Membranes
Water
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yoshida, S., Busto, R., Ginsberg, M., Abe, K., Martinez, E., Watson, B. D., & Scheinberg, P. (1983). Compression-induced brain edema: Modification by prior depletion and supplementation of vitamin E. Neurology, 33(2), 166-172.

Compression-induced brain edema : Modification by prior depletion and supplementation of vitamin E. / Yoshida, S.; Busto, R.; Ginsberg, Myron; Abe, K.; Martinez, E.; Watson, B. D.; Scheinberg, P.

In: Neurology, Vol. 33, No. 2, 07.04.1983, p. 166-172.

Research output: Contribution to journalArticle

Yoshida, S, Busto, R, Ginsberg, M, Abe, K, Martinez, E, Watson, BD & Scheinberg, P 1983, 'Compression-induced brain edema: Modification by prior depletion and supplementation of vitamin E', Neurology, vol. 33, no. 2, pp. 166-172.
Yoshida S, Busto R, Ginsberg M, Abe K, Martinez E, Watson BD et al. Compression-induced brain edema: Modification by prior depletion and supplementation of vitamin E. Neurology. 1983 Apr 7;33(2):166-172.
Yoshida, S. ; Busto, R. ; Ginsberg, Myron ; Abe, K. ; Martinez, E. ; Watson, B. D. ; Scheinberg, P. / Compression-induced brain edema : Modification by prior depletion and supplementation of vitamin E. In: Neurology. 1983 ; Vol. 33, No. 2. pp. 166-172.
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