Abstract
We studied the degree of edema resulting from focal brain compression in rats raised on vitamin E-deficient, -normal, or -supplemented diets. After release of 24 hours of epidural compression, edema developed ipsilaterally and was characterized by extravasation of serum protein, increased water and sodium content, and little change in potassium. The degree of swelling and increase of sodium in the previously compressed area were most pronounced in the vitamin E-deficient group and mildest in the vitamin E-supplemented group. Degradative processes of biomembranes seem to participate in the pathogenesis in the pathogenesis of brain edema; vitamin E may stabilize membranes by physicochemical interactions between the phytyl side chain and polyunsaturated phospholipids, or vitamin E may disrupt chains of free radical reactions.
| Original language | English |
|---|---|
| Pages (from-to) | 166-172 |
| Number of pages | 7 |
| Journal | Neurology |
| Volume | 33 |
| Issue number | 2 |
| State | Published - Apr 7 1983 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Compression-induced brain edema : Modification by prior depletion and supplementation of vitamin E. / Yoshida, S.; Busto, R.; Ginsberg, Myron; Abe, K.; Martinez, E.; Watson, B. D.; Scheinberg, P.
In: Neurology, Vol. 33, No. 2, 07.04.1983, p. 166-172.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Compression-induced brain edema
T2 - Modification by prior depletion and supplementation of vitamin E
AU - Yoshida, S.
AU - Busto, R.
AU - Ginsberg, Myron
AU - Abe, K.
AU - Martinez, E.
AU - Watson, B. D.
AU - Scheinberg, P.
PY - 1983/4/7
Y1 - 1983/4/7
N2 - We studied the degree of edema resulting from focal brain compression in rats raised on vitamin E-deficient, -normal, or -supplemented diets. After release of 24 hours of epidural compression, edema developed ipsilaterally and was characterized by extravasation of serum protein, increased water and sodium content, and little change in potassium. The degree of swelling and increase of sodium in the previously compressed area were most pronounced in the vitamin E-deficient group and mildest in the vitamin E-supplemented group. Degradative processes of biomembranes seem to participate in the pathogenesis in the pathogenesis of brain edema; vitamin E may stabilize membranes by physicochemical interactions between the phytyl side chain and polyunsaturated phospholipids, or vitamin E may disrupt chains of free radical reactions.
AB - We studied the degree of edema resulting from focal brain compression in rats raised on vitamin E-deficient, -normal, or -supplemented diets. After release of 24 hours of epidural compression, edema developed ipsilaterally and was characterized by extravasation of serum protein, increased water and sodium content, and little change in potassium. The degree of swelling and increase of sodium in the previously compressed area were most pronounced in the vitamin E-deficient group and mildest in the vitamin E-supplemented group. Degradative processes of biomembranes seem to participate in the pathogenesis in the pathogenesis of brain edema; vitamin E may stabilize membranes by physicochemical interactions between the phytyl side chain and polyunsaturated phospholipids, or vitamin E may disrupt chains of free radical reactions.
UR - http://www.scopus.com/inward/record.url?scp=0020654192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020654192&partnerID=8YFLogxK
M3 - Article
C2 - 6681657
AN - SCOPUS:0020654192
VL - 33
SP - 166
EP - 172
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 2
ER -