Comprehensive treatment of Huntington disease and other choreic disorders

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The management of choreic disorders presents significant challenges, including identifying the etiology of the disorder, treating and preventing motor symptoms, and managing a range of other neurologic and behavioral complications. Chorea may occur in several neurodegenerative, genetic, or drug-related conditions, and a thorough diagnostic evaluation is needed to identify the specific underlying causes. Some choreic disorders have specific treatable underlying etiologies, such as vitamin B12 defi-ciency or drug-induced dyskinesia. Autoimmune disorders such as Sydenham chorea may be treated with penicillin, corticosteroids, intravenous immunoglobulin, or plasma exchange. Heredodegenerative choreas such as Huntington disease often respond to treatment with tetrabenazine or amantadine. Many other agents may be used nonspecifi-cally for symptom control, including benzodiazepines, neuroleptics, and antiepileptic medications. In addition to motor symptoms, patients with Huntington disease or other choreic disorders often experience increasing depression, bradykinesia, cognitive impairment, aggressive behaviors, and other complications as the disease progresses. Caring for the caregiver is also a significant concern in the longterm treatment of choreic disorders.

Original languageEnglish
JournalCleveland Clinic Journal of Medicine
Volume79
Issue numberSUPPL.2
DOIs
StatePublished - Jan 1 2012

Fingerprint

Chorea
Huntington Disease
Drug-Induced Dyskinesia
Tetrabenazine
Amantadine
Hypokinesia
Plasma Exchange
Intravenous Immunoglobulins
Vitamin B 12
Benzodiazepines
Penicillins
Anticonvulsants
Nervous System
Caregivers
Antipsychotic Agents
Adrenal Cortex Hormones
Therapeutics
Depression
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comprehensive treatment of Huntington disease and other choreic disorders. / Singer, Carlos.

In: Cleveland Clinic Journal of Medicine, Vol. 79, No. SUPPL.2, 01.01.2012.

Research output: Contribution to journalArticle

@article{18b0378b8e2141b68dfca830f0f5570a,
title = "Comprehensive treatment of Huntington disease and other choreic disorders",
abstract = "The management of choreic disorders presents significant challenges, including identifying the etiology of the disorder, treating and preventing motor symptoms, and managing a range of other neurologic and behavioral complications. Chorea may occur in several neurodegenerative, genetic, or drug-related conditions, and a thorough diagnostic evaluation is needed to identify the specific underlying causes. Some choreic disorders have specific treatable underlying etiologies, such as vitamin B12 defi-ciency or drug-induced dyskinesia. Autoimmune disorders such as Sydenham chorea may be treated with penicillin, corticosteroids, intravenous immunoglobulin, or plasma exchange. Heredodegenerative choreas such as Huntington disease often respond to treatment with tetrabenazine or amantadine. Many other agents may be used nonspecifi-cally for symptom control, including benzodiazepines, neuroleptics, and antiepileptic medications. In addition to motor symptoms, patients with Huntington disease or other choreic disorders often experience increasing depression, bradykinesia, cognitive impairment, aggressive behaviors, and other complications as the disease progresses. Caring for the caregiver is also a significant concern in the longterm treatment of choreic disorders.",
author = "Carlos Singer",
year = "2012",
month = "1",
day = "1",
doi = "10.3949/ccjm.79.s2a.06",
language = "English",
volume = "79",
journal = "Cleveland Clinic Journal of Medicine",
issn = "0891-1150",
publisher = "Cleveland Clinic Educational Foundation",
number = "SUPPL.2",

}

TY - JOUR

T1 - Comprehensive treatment of Huntington disease and other choreic disorders

AU - Singer, Carlos

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The management of choreic disorders presents significant challenges, including identifying the etiology of the disorder, treating and preventing motor symptoms, and managing a range of other neurologic and behavioral complications. Chorea may occur in several neurodegenerative, genetic, or drug-related conditions, and a thorough diagnostic evaluation is needed to identify the specific underlying causes. Some choreic disorders have specific treatable underlying etiologies, such as vitamin B12 defi-ciency or drug-induced dyskinesia. Autoimmune disorders such as Sydenham chorea may be treated with penicillin, corticosteroids, intravenous immunoglobulin, or plasma exchange. Heredodegenerative choreas such as Huntington disease often respond to treatment with tetrabenazine or amantadine. Many other agents may be used nonspecifi-cally for symptom control, including benzodiazepines, neuroleptics, and antiepileptic medications. In addition to motor symptoms, patients with Huntington disease or other choreic disorders often experience increasing depression, bradykinesia, cognitive impairment, aggressive behaviors, and other complications as the disease progresses. Caring for the caregiver is also a significant concern in the longterm treatment of choreic disorders.

AB - The management of choreic disorders presents significant challenges, including identifying the etiology of the disorder, treating and preventing motor symptoms, and managing a range of other neurologic and behavioral complications. Chorea may occur in several neurodegenerative, genetic, or drug-related conditions, and a thorough diagnostic evaluation is needed to identify the specific underlying causes. Some choreic disorders have specific treatable underlying etiologies, such as vitamin B12 defi-ciency or drug-induced dyskinesia. Autoimmune disorders such as Sydenham chorea may be treated with penicillin, corticosteroids, intravenous immunoglobulin, or plasma exchange. Heredodegenerative choreas such as Huntington disease often respond to treatment with tetrabenazine or amantadine. Many other agents may be used nonspecifi-cally for symptom control, including benzodiazepines, neuroleptics, and antiepileptic medications. In addition to motor symptoms, patients with Huntington disease or other choreic disorders often experience increasing depression, bradykinesia, cognitive impairment, aggressive behaviors, and other complications as the disease progresses. Caring for the caregiver is also a significant concern in the longterm treatment of choreic disorders.

UR - http://www.scopus.com/inward/record.url?scp=84868314116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868314116&partnerID=8YFLogxK

U2 - 10.3949/ccjm.79.s2a.06

DO - 10.3949/ccjm.79.s2a.06

M3 - Article

C2 - 22761268

AN - SCOPUS:84868314116

VL - 79

JO - Cleveland Clinic Journal of Medicine

JF - Cleveland Clinic Journal of Medicine

SN - 0891-1150

IS - SUPPL.2

ER -