Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy

Varan Govind, Khema R Sharma, Andrew A Maudsley, Kristopher Arheart, Gaurav Saigal, Sulaiman Sheriff

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Changes in the distribution of the proton magnetic resonance spectroscopy (MRS) observed metabolites N-acetyl aspartate (NAA), total-choline (Cho), and total-creatine (Cre) in the entire intracranial corticospinal tract (CST) including the primary motor cortex were evaluated in patients with amyotrophic lateral sclerosis (ALS). The study included 38 sporadic definite-ALS subjects and 70 age-matched control subjects. All received whole-brain MR imaging and spectroscopic imaging scans at 3T and clinical neurological assessments including percentage maximum forced vital capacity (FVC) and upper motor neuron (UMN) function. Differences in each individual metabolite and its ratio distributions were evaluated in the entire intracranial CST and in five segments along the length of the CST (at the levels of precentral gyrus (PCG), centrum semiovale (CS), corona radiata (CR), posterior limb of internal capsule (PLIC) and cerebral peduncle (CP)). Major findings included significantly decreased NAA and increased Cho and Cho/NAA in the entire intracranial CST, with the largest differences for Cho/NAA in all the groups. Significant correlations between Cho/NAA in the entire intracranial CST and the right finger tap rate were noted. Of the ten bilateral CST segments, significantly decreased NAA in 4 segments, increased Cho in 5 segments and increased Cho/NAA in all the segments were found. Significant left versus right CST asymmetries were found only in ALS for Cho/NAA in the CS. Among the significant correlations found between Cho/NAA and the clinical assessments included the left-PCG versus FVC and right finger tap rate, left -CR versus FVC and right finger tap rate, and left PLIC versus FVC and right foot tap rate. These results demonstrate that a significant and bilaterally asymmetric alteration of metabolites occurs along the length of the entire intracranial CST in ALS, and the MRS metrics in the segments correlate with measures of disease severity and UMN function.

Original languageEnglish
Article numbere35607
JournalPLoS One
Volume7
Issue number4
DOIs
StatePublished - Apr 23 2012

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Pyramidal Tracts
Amyotrophic Lateral Sclerosis
aspartic acid
choline
Metabolites
Choline
spectroscopy
Brain
Magnetic Resonance Spectroscopy
Spectroscopy
metabolites
brain
Vital Capacity
Magnetic resonance spectroscopy
Fingers
Internal Capsule
Frontal Lobe
motor neurons
limbs (animal)
Neurons

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy. / Govind, Varan; Sharma, Khema R; Maudsley, Andrew A; Arheart, Kristopher; Saigal, Gaurav; Sheriff, Sulaiman.

In: PLoS One, Vol. 7, No. 4, e35607, 23.04.2012.

Research output: Contribution to journalArticle

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