Comprehensive analysis of Hox gene expression in the amphipod crustacean Parhyale hawaiensis

Julia M. Serano, Arnaud Martin, Danielle M. Liubicich, Erin Jarvis, Heather S. Bruce, Konnor La, William E. Browne, Jane Grimwood, Nipam H. Patel

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Hox genes play crucial roles in establishing regional identity along the anterior-posterior axis in bilaterian animals, and have been implicated in generating morphological diversity throughout evolution. Here we report the identification, expression, and initial genomic characterization of the complete set of Hox genes from the amphipod crustacean Parhyale hawaiensis. Parhyale is an emerging model system that is amenable to experimental manipulations and evolutionary comparisons among the arthropods. Our analyses indicate that the Parhyale genome contains a single copy of each canonical Hox gene with the exception of fushi tarazu, and preliminary mapping suggests that at least some of these genes are clustered together in the genome. With few exceptions, Parhyale Hox genes exhibit both temporal and spatial colinearity, and expression boundaries correlate with morphological differences between segments and their associated appendages. This work represents the most comprehensive analysis of Hox gene expression in a crustacean to date, and provides a foundation for functional studies aimed at elucidating the role of Hox genes in arthropod development and evolution.

Original languageEnglish (US)
Pages (from-to)297-309
Number of pages13
JournalDevelopmental Biology
Volume409
Issue number1
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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    Serano, J. M., Martin, A., Liubicich, D. M., Jarvis, E., Bruce, H. S., La, K., Browne, W. E., Grimwood, J., & Patel, N. H. (2016). Comprehensive analysis of Hox gene expression in the amphipod crustacean Parhyale hawaiensis. Developmental Biology, 409(1), 297-309. https://doi.org/10.1016/j.ydbio.2015.10.029