Abstract
Hox genes play crucial roles in establishing regional identity along the anterior-posterior axis in bilaterian animals, and have been implicated in generating morphological diversity throughout evolution. Here we report the identification, expression, and initial genomic characterization of the complete set of Hox genes from the amphipod crustacean Parhyale hawaiensis. Parhyale is an emerging model system that is amenable to experimental manipulations and evolutionary comparisons among the arthropods. Our analyses indicate that the Parhyale genome contains a single copy of each canonical Hox gene with the exception of fushi tarazu, and preliminary mapping suggests that at least some of these genes are clustered together in the genome. With few exceptions, Parhyale Hox genes exhibit both temporal and spatial colinearity, and expression boundaries correlate with morphological differences between segments and their associated appendages. This work represents the most comprehensive analysis of Hox gene expression in a crustacean to date, and provides a foundation for functional studies aimed at elucidating the role of Hox genes in arthropod development and evolution.
| Original language | English (US) |
|---|---|
| Journal | Developmental Biology |
| DOIs | |
| State | Accepted/In press - Sep 6 2015 |
Fingerprint
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
- Molecular Biology
Cite this
Comprehensive analysis of Hox gene expression in the amphipod crustacean Parhyale hawaiensis. / Serano, Julia M.; Martin, Arnaud; Liubicich, Danielle M.; Jarvis, Erin; Bruce, Heather S.; La, Konnor; Browne, William; Grimwood, Jane; Patel, Nipam H.
In: Developmental Biology, 06.09.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comprehensive analysis of Hox gene expression in the amphipod crustacean Parhyale hawaiensis
AU - Serano, Julia M.
AU - Martin, Arnaud
AU - Liubicich, Danielle M.
AU - Jarvis, Erin
AU - Bruce, Heather S.
AU - La, Konnor
AU - Browne, William
AU - Grimwood, Jane
AU - Patel, Nipam H.
PY - 2015/9/6
Y1 - 2015/9/6
N2 - Hox genes play crucial roles in establishing regional identity along the anterior-posterior axis in bilaterian animals, and have been implicated in generating morphological diversity throughout evolution. Here we report the identification, expression, and initial genomic characterization of the complete set of Hox genes from the amphipod crustacean Parhyale hawaiensis. Parhyale is an emerging model system that is amenable to experimental manipulations and evolutionary comparisons among the arthropods. Our analyses indicate that the Parhyale genome contains a single copy of each canonical Hox gene with the exception of fushi tarazu, and preliminary mapping suggests that at least some of these genes are clustered together in the genome. With few exceptions, Parhyale Hox genes exhibit both temporal and spatial colinearity, and expression boundaries correlate with morphological differences between segments and their associated appendages. This work represents the most comprehensive analysis of Hox gene expression in a crustacean to date, and provides a foundation for functional studies aimed at elucidating the role of Hox genes in arthropod development and evolution.
AB - Hox genes play crucial roles in establishing regional identity along the anterior-posterior axis in bilaterian animals, and have been implicated in generating morphological diversity throughout evolution. Here we report the identification, expression, and initial genomic characterization of the complete set of Hox genes from the amphipod crustacean Parhyale hawaiensis. Parhyale is an emerging model system that is amenable to experimental manipulations and evolutionary comparisons among the arthropods. Our analyses indicate that the Parhyale genome contains a single copy of each canonical Hox gene with the exception of fushi tarazu, and preliminary mapping suggests that at least some of these genes are clustered together in the genome. With few exceptions, Parhyale Hox genes exhibit both temporal and spatial colinearity, and expression boundaries correlate with morphological differences between segments and their associated appendages. This work represents the most comprehensive analysis of Hox gene expression in a crustacean to date, and provides a foundation for functional studies aimed at elucidating the role of Hox genes in arthropod development and evolution.
UR - http://www.scopus.com/inward/record.url?scp=84947335358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947335358&partnerID=8YFLogxK
U2 - 10.1016/j.ydbio.2015.10.029
DO - 10.1016/j.ydbio.2015.10.029
M3 - Article
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
ER -