Compliance effect on amplidue and phase of cranio-spinal CSF flow measrured by MRI

Rong Wen Tain, Noam Alperin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Intracranial compliance (ICC) determines the ability of the intracranial space to accommodate increase in volume without a large increase in pressure. Indirect and direct approaches have been proposed for magnetic resonance imaging (MRI)-based noninvasive estimation of ICC from measured cerebral blood and cerebral spinal fluid (CSF) flow dynamics to and from the cranium during the cardiac cycle. The indirect measures are based on phase lag between the CSF flow and its driving force, either arterial inflow or net transcranial blood flow. The direct approach estimates ICC from the ratio of the volume and pressure changes during the cardiac cycle. This study compares the sensitivity of indirect and direct measures of ICC to changes in ICC. In vivo volumetric blood and CSF flows measured by MRI phase contrast from healthy volunteers and from patients with elevated ICP were used for the comparison. We utilized an RLC circuit model of the cranio-spinal system to simulate the effect of a change in ICC on the CSF flow waveform. These simulations quantify the affect of changes in intracranial compliance on phase and amplitude and further demonstrate that amplitude based measures such as the one used in the direct approach are a more sensitive and reliable estimate of ICC than the phase based indirect approach.

Original languageEnglish
Title of host publication3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
DOIs
StatePublished - Dec 31 2009
Externally publishedYes
Event3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 - Beijing, China
Duration: Jun 11 2009Jun 13 2009

Other

Other3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
CountryChina
CityBeijing
Period6/11/096/13/09

Fingerprint

Magnetic resonance
Compliance
Flow of fluids
Magnetic Resonance Imaging
Imaging techniques
Blood
Pressure
Aptitude
Hydrodynamics
Skull
Healthy Volunteers
Networks (circuits)

Keywords

  • Cerebral spinal fluid (CSF) flow
  • Intracranial compliance
  • Lumped-parameter modeling
  • Magnetic resonance imaging (MRI)

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

Cite this

Tain, R. W., & Alperin, N. (2009). Compliance effect on amplidue and phase of cranio-spinal CSF flow measrured by MRI. In 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 [5162546] https://doi.org/10.1109/ICBBE.2009.5162546

Compliance effect on amplidue and phase of cranio-spinal CSF flow measrured by MRI. / Tain, Rong Wen; Alperin, Noam.

3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009. 2009. 5162546.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tain, RW & Alperin, N 2009, Compliance effect on amplidue and phase of cranio-spinal CSF flow measrured by MRI. in 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009., 5162546, 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009, Beijing, China, 6/11/09. https://doi.org/10.1109/ICBBE.2009.5162546
Tain RW, Alperin N. Compliance effect on amplidue and phase of cranio-spinal CSF flow measrured by MRI. In 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009. 2009. 5162546 https://doi.org/10.1109/ICBBE.2009.5162546
Tain, Rong Wen ; Alperin, Noam. / Compliance effect on amplidue and phase of cranio-spinal CSF flow measrured by MRI. 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009. 2009.
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