Complex wound management with an artificial dermal regeneration template

Sean Simon, Jeff Hammoudeh, Christopher Low, Nirmal Nathan, Milton Armstrong, Seth Thaller

Research output: Contribution to journalArticle

Abstract

The following case reports on the successful use of Integra® (Integra LifeSciences, Plainsboro, NJ) as an alternative for coverage of exposed tibia in a patient with necrotizing fasciitis and significant comorbidities. Necrotizing fasciitis is a generalized term that is used to describe soft tissue infections in which necrosis of the fascia and subcutaneous tissue occurs. Necrotizing fasciitis will often begin with disproportionate pain, localized erythema, and skin discoloration with vesicle formation. As the disease progresses along fascial planes, an area of deep necrosis develops with eventual signs of systemic toxicity and sepsis. Diagnosis of this condition can be quite challenging, and the diagnostic value of laboratory tests is limited. Aggressive treatment of necrotizing fasciitis is extremely important; the infection develops rapidly and can quickly lead to systemic toxicity and death. Traditionally, management of necrotizing fasciitis consists of resuscitation and stabilization of the patient, aggressive surgical debridement of all nonviable tissue, and the administration of broad-spectrum antibiotics. Reconstructive surgery is indicated for many patients who have recovered from necrotizing fasciitis. Integra, an artificial dermal regeneration template (DRT), has emerged as an adjunct to split-thickness grafts or tissue transfers. This case exemplifies the potential for DRT to provide another, more direct alternative for coverage of a complex, exposed wound.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalWounds
Volume20
Issue number11
StatePublished - Nov 1 2008

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Artificial Skin
Necrotizing Fasciitis
Regeneration
Wounds and Injuries
Reconstructive Surgical Procedures
Necrosis
Skin
Soft Tissue Infections
Fascia
Subcutaneous Tissue
Debridement
Erythema
Tibia
Resuscitation
Comorbidity
Sepsis
Anti-Bacterial Agents
Transplants
Pain
Infection

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

Cite this

Simon, S., Hammoudeh, J., Low, C., Nathan, N., Armstrong, M., & Thaller, S. (2008). Complex wound management with an artificial dermal regeneration template. Wounds, 20(11), 299-302.

Complex wound management with an artificial dermal regeneration template. / Simon, Sean; Hammoudeh, Jeff; Low, Christopher; Nathan, Nirmal; Armstrong, Milton; Thaller, Seth.

In: Wounds, Vol. 20, No. 11, 01.11.2008, p. 299-302.

Research output: Contribution to journalArticle

Simon, S, Hammoudeh, J, Low, C, Nathan, N, Armstrong, M & Thaller, S 2008, 'Complex wound management with an artificial dermal regeneration template', Wounds, vol. 20, no. 11, pp. 299-302.
Simon S, Hammoudeh J, Low C, Nathan N, Armstrong M, Thaller S. Complex wound management with an artificial dermal regeneration template. Wounds. 2008 Nov 1;20(11):299-302.
Simon, Sean ; Hammoudeh, Jeff ; Low, Christopher ; Nathan, Nirmal ; Armstrong, Milton ; Thaller, Seth. / Complex wound management with an artificial dermal regeneration template. In: Wounds. 2008 ; Vol. 20, No. 11. pp. 299-302.
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