TY - JOUR
T1 - Complex of aminoacyl-transfer RNA synthetases
AU - Bandyopadhyay, Alok Kumar
AU - Deutscher, Murray P.
PY - 1971/8/28
Y1 - 1971/8/28
N2 - A high molecular weight complex has been isolated from rat liver which contains all the aminoacyl-transfer RNA synthetases and and a large proportion of the tRNA present in the high-speed supernatant fraction. The complex could be partially purified by chromatography on Sephadex G200 and Sepharose 6B. The complex could be disrupted by excess homogenization and freezing and thawing with a concomitant decrease in the activities of the aminoacyl-tRNA synthetases. The results suggest that some of the presumed "soluble" components of the protein synthetic apparatus may be present in highly organized structures within the cell.
AB - A high molecular weight complex has been isolated from rat liver which contains all the aminoacyl-transfer RNA synthetases and and a large proportion of the tRNA present in the high-speed supernatant fraction. The complex could be partially purified by chromatography on Sephadex G200 and Sepharose 6B. The complex could be disrupted by excess homogenization and freezing and thawing with a concomitant decrease in the activities of the aminoacyl-tRNA synthetases. The results suggest that some of the presumed "soluble" components of the protein synthetic apparatus may be present in highly organized structures within the cell.
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U2 - 10.1016/0022-2836(71)90451-7
DO - 10.1016/0022-2836(71)90451-7
M3 - Article
C2 - 5572099
AN - SCOPUS:0015243504
VL - 60
SP - 113
EP - 122
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
SN - 0022-2836
IS - 1
ER -