Complete genome sequence of an M1 strain of streptococcus pyogenes

Joseph J. Ferretti, William M. McShan, Dragana Ajdic, Dragutin J. Savic, Gorana Savic, Kevin Lyon, Charles Primeaux, Steven Sezate, Alexander N. Suvorov, Steve Kenton, Hong Shing Lai, Shao Ping Lin, Yudong Qian, Hong Gui Jia, Fares Z. Najar, Qun Ren, Hua Zhu, Lin Song, Jim White, Xiling Yuan & 3 others Sandra W. Clifton, Bruce A. Roe, Robert McLaughlin

Research output: Contribution to journalArticle

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Abstract

The 1,852,442-bp sequence of an M1 strain of Streptococcus pyogenes, a Gram-positive pathogen, has been determined and contains 1,752 predicted protein-encoding genes. Approximately one-third of these genes have no identifiable function, with the remainder falling into previously characterized categories of known microbial function. Consistent with the observation that S. pyogenes is responsible for a wider variety of human disease than any other bacterial species, more than 40 putative virulence-associated genes have been identified. Additional genes have been identified that encode proteins likely associated with microbial "molecular mimicry" of host characteristics and involved in rheumatic fever or acute glomerulonephritis. The complete or partial sequence of four different bacteriophage genomes is also present, with each containing genes for one or more previously undiscovered superantigen-like proteins. These prophage-associated genes encode at least six potential virulence factors, emphasizing the importance of bacteriophages in horizontal gene transfer and a possible mechanism for generating new strains with increased pathogenic potential.

Original languageEnglish
Pages (from-to)4658-4663
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number8
DOIs
StatePublished - Apr 10 2001
Externally publishedYes

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Streptococcus pyogenes
Genome
Genes
Bacteriophages
Molecular Mimicry
Prophages
Horizontal Gene Transfer
Superantigens
Proteins
Rheumatic Fever
Virulence Factors
Glomerulonephritis
Virulence

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Complete genome sequence of an M1 strain of streptococcus pyogenes. / Ferretti, Joseph J.; McShan, William M.; Ajdic, Dragana; Savic, Dragutin J.; Savic, Gorana; Lyon, Kevin; Primeaux, Charles; Sezate, Steven; Suvorov, Alexander N.; Kenton, Steve; Lai, Hong Shing; Lin, Shao Ping; Qian, Yudong; Jia, Hong Gui; Najar, Fares Z.; Ren, Qun; Zhu, Hua; Song, Lin; White, Jim; Yuan, Xiling; Clifton, Sandra W.; Roe, Bruce A.; McLaughlin, Robert.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 8, 10.04.2001, p. 4658-4663.

Research output: Contribution to journalArticle

Ferretti, JJ, McShan, WM, Ajdic, D, Savic, DJ, Savic, G, Lyon, K, Primeaux, C, Sezate, S, Suvorov, AN, Kenton, S, Lai, HS, Lin, SP, Qian, Y, Jia, HG, Najar, FZ, Ren, Q, Zhu, H, Song, L, White, J, Yuan, X, Clifton, SW, Roe, BA & McLaughlin, R 2001, 'Complete genome sequence of an M1 strain of streptococcus pyogenes', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 8, pp. 4658-4663. https://doi.org/10.1073/pnas.071559398
Ferretti, Joseph J. ; McShan, William M. ; Ajdic, Dragana ; Savic, Dragutin J. ; Savic, Gorana ; Lyon, Kevin ; Primeaux, Charles ; Sezate, Steven ; Suvorov, Alexander N. ; Kenton, Steve ; Lai, Hong Shing ; Lin, Shao Ping ; Qian, Yudong ; Jia, Hong Gui ; Najar, Fares Z. ; Ren, Qun ; Zhu, Hua ; Song, Lin ; White, Jim ; Yuan, Xiling ; Clifton, Sandra W. ; Roe, Bruce A. ; McLaughlin, Robert. / Complete genome sequence of an M1 strain of streptococcus pyogenes. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 8. pp. 4658-4663.
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AU - Primeaux, Charles

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AU - Song, Lin

AU - White, Jim

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AU - Roe, Bruce A.

AU - McLaughlin, Robert

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