Complementary roles of BDNF and NT-3 in vestibular and auditory development

Patrik Ernfors, Thomas R Van De Water, Janet Loring, Rudolf Jaenisch

Research output: Contribution to journalArticle

379 Citations (Scopus)

Abstract

The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth of nerve fibers into the vestibular epithelium, but BDNF mutants failed to maintain afferent and efferent innervation. In the cochlea, BDNF mutants lost type 2 spiral neurons, causing an absence of outer hair cell innervation. NT-3 mutantsshowed a paucity of afferents and lost 87% of spiral neurons, presumably corresponding to type 1 neurons, which innervate inner hair cells. Double mutants had an additive loss, lacking all vestibular and spiral neurons. These results show that BDNF and NT-3 are crucial for inner ear development and, although largely coexpressed, have distinct and nonoverlapping roles in the vestibular and auditory systems.

Original languageEnglish
Pages (from-to)1153-1164
Number of pages12
JournalNeuron
Volume14
Issue number6
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Neurons
Outer Auditory Hair Cells
Inner Auditory Hair Cells
Spiral Ganglion
Cochlea
Inner Ear
Nerve Fibers
Ganglia
Epithelium
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ernfors, P., Van De Water, T. R., Loring, J., & Jaenisch, R. (1995). Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron, 14(6), 1153-1164. https://doi.org/10.1016/0896-6273(95)90263-5

Complementary roles of BDNF and NT-3 in vestibular and auditory development. / Ernfors, Patrik; Van De Water, Thomas R; Loring, Janet; Jaenisch, Rudolf.

In: Neuron, Vol. 14, No. 6, 01.01.1995, p. 1153-1164.

Research output: Contribution to journalArticle

Ernfors, P, Van De Water, TR, Loring, J & Jaenisch, R 1995, 'Complementary roles of BDNF and NT-3 in vestibular and auditory development', Neuron, vol. 14, no. 6, pp. 1153-1164. https://doi.org/10.1016/0896-6273(95)90263-5
Ernfors, Patrik ; Van De Water, Thomas R ; Loring, Janet ; Jaenisch, Rudolf. / Complementary roles of BDNF and NT-3 in vestibular and auditory development. In: Neuron. 1995 ; Vol. 14, No. 6. pp. 1153-1164.
@article{f77b127190854ec6b37f8ad954de8332,
title = "Complementary roles of BDNF and NT-3 in vestibular and auditory development",
abstract = "The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth of nerve fibers into the vestibular epithelium, but BDNF mutants failed to maintain afferent and efferent innervation. In the cochlea, BDNF mutants lost type 2 spiral neurons, causing an absence of outer hair cell innervation. NT-3 mutantsshowed a paucity of afferents and lost 87{\%} of spiral neurons, presumably corresponding to type 1 neurons, which innervate inner hair cells. Double mutants had an additive loss, lacking all vestibular and spiral neurons. These results show that BDNF and NT-3 are crucial for inner ear development and, although largely coexpressed, have distinct and nonoverlapping roles in the vestibular and auditory systems.",
author = "Patrik Ernfors and {Van De Water}, {Thomas R} and Janet Loring and Rudolf Jaenisch",
year = "1995",
month = "1",
day = "1",
doi = "10.1016/0896-6273(95)90263-5",
language = "English",
volume = "14",
pages = "1153--1164",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Complementary roles of BDNF and NT-3 in vestibular and auditory development

AU - Ernfors, Patrik

AU - Van De Water, Thomas R

AU - Loring, Janet

AU - Jaenisch, Rudolf

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth of nerve fibers into the vestibular epithelium, but BDNF mutants failed to maintain afferent and efferent innervation. In the cochlea, BDNF mutants lost type 2 spiral neurons, causing an absence of outer hair cell innervation. NT-3 mutantsshowed a paucity of afferents and lost 87% of spiral neurons, presumably corresponding to type 1 neurons, which innervate inner hair cells. Double mutants had an additive loss, lacking all vestibular and spiral neurons. These results show that BDNF and NT-3 are crucial for inner ear development and, although largely coexpressed, have distinct and nonoverlapping roles in the vestibular and auditory systems.

AB - The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth of nerve fibers into the vestibular epithelium, but BDNF mutants failed to maintain afferent and efferent innervation. In the cochlea, BDNF mutants lost type 2 spiral neurons, causing an absence of outer hair cell innervation. NT-3 mutantsshowed a paucity of afferents and lost 87% of spiral neurons, presumably corresponding to type 1 neurons, which innervate inner hair cells. Double mutants had an additive loss, lacking all vestibular and spiral neurons. These results show that BDNF and NT-3 are crucial for inner ear development and, although largely coexpressed, have distinct and nonoverlapping roles in the vestibular and auditory systems.

UR - http://www.scopus.com/inward/record.url?scp=0029014667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029014667&partnerID=8YFLogxK

U2 - 10.1016/0896-6273(95)90263-5

DO - 10.1016/0896-6273(95)90263-5

M3 - Article

C2 - 7605630

AN - SCOPUS:0029014667

VL - 14

SP - 1153

EP - 1164

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 6

ER -