Complementary detection of prostate-specific antigen using In 2O3 nanowires and carbon nanotubes

Chao Li, Marco Curreli, Henry Lin, Bo Lei, F. N. Ishikawa, Ram Datar, Richard J. Cote, Mark E. Thompson, Chongwu Zhou

Research output: Contribution to journalArticle

350 Scopus citations

Abstract

We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.

Original languageEnglish (US)
Pages (from-to)12484-12485
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number36
DOIs
StatePublished - Sep 14 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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    Li, C., Curreli, M., Lin, H., Lei, B., Ishikawa, F. N., Datar, R., Cote, R. J., Thompson, M. E., & Zhou, C. (2005). Complementary detection of prostate-specific antigen using In 2O3 nanowires and carbon nanotubes. Journal of the American Chemical Society, 127(36), 12484-12485. https://doi.org/10.1021/ja053761g