Complement activation in patients undergoing mechanical circulatory support

Matthias Loebe; Kiron Gorman; Roland Burger; Jonathan E. Gage; Conni Harke; Roland Hetzer

doi:10.1097/00002480-199809000-00004

Complement activation in patients undergoing mechanical circulatory support

Matthias Loebe, Kiron Gorman, Roland Burger, Jonathan E. Gage, Conni Harke, Roland Hetzer

Surgery

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The course and prognostic value of complement factors C3a and C5a in 66 patients supported with pulsatile ventricular assist devices are examined. Some patients were given the Berlin Heart biventricular assist device (BVAD) implant, the Novacor left ventricular assist device (LVAD), or the HeartMate Thermo Cardiosystems LVAD. Significant differences in contact activation were found after implantation of the device since all three devices have distinctive inner surface patterns. High levels of complement activation were also observed before implantation of a device in patients needing biventricular support than in those requiring only left ventricular assistance.

Original language	English (US)
Pages (from-to)	M340-M346
Journal	ASAIO Journal
Volume	44
Issue number	5
DOIs	https://doi.org/10.1097/00002480-199809000-00004
State	Published - 1998

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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title = "Complement activation in patients undergoing mechanical circulatory support",

abstract = "The course and prognostic value of complement factors C3a and C5a in 66 patients supported with pulsatile ventricular assist devices are examined. Some patients were given the Berlin Heart biventricular assist device (BVAD) implant, the Novacor left ventricular assist device (LVAD), or the HeartMate Thermo Cardiosystems LVAD. Significant differences in contact activation were found after implantation of the device since all three devices have distinctive inner surface patterns. High levels of complement activation were also observed before implantation of a device in patients needing biventricular support than in those requiring only left ventricular assistance.",

author = "Matthias Loebe and Kiron Gorman and Roland Burger and Gage, {Jonathan E.} and Conni Harke and Roland Hetzer",

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AU - Loebe, Matthias

AU - Gorman, Kiron

AU - Burger, Roland

AU - Gage, Jonathan E.

AU - Harke, Conni

AU - Hetzer, Roland

PY - 1998

Y1 - 1998

N2 - The course and prognostic value of complement factors C3a and C5a in 66 patients supported with pulsatile ventricular assist devices are examined. Some patients were given the Berlin Heart biventricular assist device (BVAD) implant, the Novacor left ventricular assist device (LVAD), or the HeartMate Thermo Cardiosystems LVAD. Significant differences in contact activation were found after implantation of the device since all three devices have distinctive inner surface patterns. High levels of complement activation were also observed before implantation of a device in patients needing biventricular support than in those requiring only left ventricular assistance.

AB - The course and prognostic value of complement factors C3a and C5a in 66 patients supported with pulsatile ventricular assist devices are examined. Some patients were given the Berlin Heart biventricular assist device (BVAD) implant, the Novacor left ventricular assist device (LVAD), or the HeartMate Thermo Cardiosystems LVAD. Significant differences in contact activation were found after implantation of the device since all three devices have distinctive inner surface patterns. High levels of complement activation were also observed before implantation of a device in patients needing biventricular support than in those requiring only left ventricular assistance.

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