Complement activation in patients undergoing mechanical circulatory support

Matthias Loebe, Kiron Gorman, Roland Burger, Jonathan E. Gage, Conni Harke, Roland Hetzer

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The course and prognostic value of complement factors C3a and C5a in 66 patients supported with pulsatile ventricular assist devices are examined. Some patients were given the Berlin Heart biventricular assist device (BVAD) implant, the Novacor left ventricular assist device (LVAD), or the HeartMate Thermo Cardiosystems LVAD. Significant differences in contact activation were found after implantation of the device since all three devices have distinctive inner surface patterns. High levels of complement activation were also observed before implantation of a device in patients needing biventricular support than in those requiring only left ventricular assistance.

Original languageEnglish (US)
Pages (from-to)M340-M346
JournalASAIO Journal
Issue number5
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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