Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome.

Roland Schein, R. Bergman, E. H. Marcial, D. Schultz, R. C. Duncan, P. I. Arnold, C. L. Sprung

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Fifty-nine patients in septic shock were observed for the development of the adult respiratory distress syndrome (ARDS) prior to and after receiving either 30 mg/kg methylprednisolone sodium succinate, 6 mg/kg dexamethasone sodium phosphate or no steroid. Serum levels of C3, C4 and Factor B allowed classification of 42 patients by activation of complement pathways. Despite a trend toward patients with severe septic shock who activate the alternative pathway being protected from the development of ARDS, complement pathway determination did not allow prediction of the development of ARDS and steroid pretreatment did not influence complement levels or prevent ARDS.

Original languageEnglish
Pages (from-to)850-854
Number of pages5
JournalChest
Volume91
Issue number6
StatePublished - Jun 1 1987
Externally publishedYes

Fingerprint

Complement Activation
Adult Respiratory Distress Syndrome
Adrenal Cortex Hormones
dexamethasone 21-phosphate
Septic Shock
Methylprednisolone Hemisuccinate
Steroids
Patient Participation
Therapeutics
Serum

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Schein, R., Bergman, R., Marcial, E. H., Schultz, D., Duncan, R. C., Arnold, P. I., & Sprung, C. L. (1987). Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome. Chest, 91(6), 850-854.

Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome. / Schein, Roland; Bergman, R.; Marcial, E. H.; Schultz, D.; Duncan, R. C.; Arnold, P. I.; Sprung, C. L.

In: Chest, Vol. 91, No. 6, 01.06.1987, p. 850-854.

Research output: Contribution to journalArticle

Schein, R, Bergman, R, Marcial, EH, Schultz, D, Duncan, RC, Arnold, PI & Sprung, CL 1987, 'Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome.', Chest, vol. 91, no. 6, pp. 850-854.
Schein R, Bergman R, Marcial EH, Schultz D, Duncan RC, Arnold PI et al. Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome. Chest. 1987 Jun 1;91(6):850-854.
Schein, Roland ; Bergman, R. ; Marcial, E. H. ; Schultz, D. ; Duncan, R. C. ; Arnold, P. I. ; Sprung, C. L. / Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome. In: Chest. 1987 ; Vol. 91, No. 6. pp. 850-854.
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