Competition of hospital-acquired and community-acquired methicillin-resistant Staphylococcus aureus strains in hospitals

Glenn F. Webb, Mary Ann Horn, Erika M.C. D'Agata, Robert C. Moellering, Shigui Ruan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Recently, we [E.M.C. D'Agata, G.F. Webb, M.A. Horn, R.C. Moellering Jr., and S. Ruan, Modelling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into the hospital setting, Clin. Infect. Dis. 48 (2009), pp. 274-284] proposed a deterministic mathematical model to characterize the factors contributing to the replacement of hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) with the community-acquired MRSA (CA-MRSA) and to quantify the effectiveness of interventions aimed at limiting the spread of CA-MRSA in the hospital setting. Numerical simulations of the model strongly suggest that CA-MRSA will become the dominant MRSA strain in the hospital setting. In this companion paper, we provide steady-state analysis and more numerical simulations of the model. It is shown that when no colonized or infected patients enter the hospital, competitive exclusion of HA-MRSA by CA-MRSA will occur with increased severity of CA-MRSA infections resulting in longer hospitalizations and a larger in-hospital reservoir of CA-MRSA. Improving compliance with hand hygiene and decolonization of CA-MRSA carriers are effective control strategies.

Original languageEnglish (US)
Pages (from-to)115-129
Number of pages15
JournalJournal of biological dynamics
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2010

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Keywords

  • Basic reproduction number
  • Competition exclusion
  • Disease-free and endemic steady states
  • Epidemic model
  • Transmission dynamics

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

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