Comparisons of scintigraphy with In-111 leukocytes and Ga-67 in the diagnosis of occult sepsis

George N Sfakianakis, W. Al-Sheikh, A. Heal, G. Rodman, R. Zeppa, Aldo N Serafini

Research output: Contribution to journalArticle

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Abstract

In a prospective study involving 32 patients with clinical suspicion of focal infection, the sensitivity and specificity of In-111-labeled leukocyte (In-WBC) scintigraphy were compared with those of Ga-67 scintigraphy performed 24-48 hr later. Of a total of 192 body sites studied, 26 foci of infection were diagnosed by aspiration, cultures, or chest radiographs. Indium-WBC indicated 19 (73%) true-positive (TP) and four (2.5%) false-positive (FP) foci of abnormal accretion; Ga-67 had 21 (81%) TP and 15 (9%) FP. The 7/26 (27%) false-negative (FN) In-WBC scintigrams involved infection foci of more than 2-wk duration; the 5/26 (19%) FN Ga-67 studies were in patients with infections manifested for <1 wk. The results of this study are useful in considering the indications of the two tracers.

Original languageEnglish
Pages (from-to)618-626
Number of pages9
JournalJournal of Nuclear Medicine
Volume23
Issue number7
StatePublished - Sep 20 1982

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Radionuclide Imaging
Sepsis
Leukocytes
Infection
Focal Infection
Indium
Thorax
Prospective Studies
Sensitivity and Specificity

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Sfakianakis, G. N., Al-Sheikh, W., Heal, A., Rodman, G., Zeppa, R., & Serafini, A. N. (1982). Comparisons of scintigraphy with In-111 leukocytes and Ga-67 in the diagnosis of occult sepsis. Journal of Nuclear Medicine, 23(7), 618-626.

Comparisons of scintigraphy with In-111 leukocytes and Ga-67 in the diagnosis of occult sepsis. / Sfakianakis, George N; Al-Sheikh, W.; Heal, A.; Rodman, G.; Zeppa, R.; Serafini, Aldo N.

In: Journal of Nuclear Medicine, Vol. 23, No. 7, 20.09.1982, p. 618-626.

Research output: Contribution to journalArticle

Sfakianakis, GN, Al-Sheikh, W, Heal, A, Rodman, G, Zeppa, R & Serafini, AN 1982, 'Comparisons of scintigraphy with In-111 leukocytes and Ga-67 in the diagnosis of occult sepsis', Journal of Nuclear Medicine, vol. 23, no. 7, pp. 618-626.
Sfakianakis, George N ; Al-Sheikh, W. ; Heal, A. ; Rodman, G. ; Zeppa, R. ; Serafini, Aldo N. / Comparisons of scintigraphy with In-111 leukocytes and Ga-67 in the diagnosis of occult sepsis. In: Journal of Nuclear Medicine. 1982 ; Vol. 23, No. 7. pp. 618-626.
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