Comparison of various indices in identifying insulin resistance and diabetes in chronic spinal cord injury

Gary J. Farkas, Phillip S. Gordon, Nareka Trewick, Ashraf S. Gorgey, David R. Dolbow, Eduard Tiozzo, Arthur S. Berg, David R. Gater

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this screening and diagnostic study was to examine the accord among indices of glucose metabolism, including the Homeostatic Model Assessment for Insulin Resistance (HOMA), HOMA2, Matsuda Index, Quantitative Insulin-sensitivity Check Index (QUICKI), hemoglobin A1C (HbA1C), and fasting plasma glucose (FPG) against intravenous glucose tolerance testmeasured insulin sensitivity (Si) in individuals with chronic motor complete SCI. Persons with chronic (≥12-months post-injury) SCI (n = 29; 79% men; age 42.2 ± 11.4; body mass index 28.6 ± 6.4 kg/m2; C4-T10) were included. Measures were compared using adjusted R2 from linear regression models with Akaike information criterion (AIC, a measure of error). QUCKI had the greatest agreement with Si (adjusted R2 = 0.463, AIC = 91.1, p = 0.0001), followed by HOMA (adjusted R2 = 0.378, AIC = 95.4, p = 0.0008), HOMA2 (adjusted R2 = 0.256, AIC = 99.7, p = 0.0030), and the Matsuda Index (adjusted R2 = 0.356, AIC = 95.5, p = 0.0004). FPG (adjusted R2 = 0.056, AIC = 107.5, p = 0.1799) and HbA1C (adjusted R2 = 0.1, AIC = 106.1, p = 0.0975) had poor agreement with Si. While HbA1C and FPG are commonly used for evaluating disorders of glucose metabolism, QUICKI demonstrates the best accord with Si compared to the other measures.

Original languageEnglish (US)
Article number5591
JournalJournal of Clinical Medicine
Volume10
Issue number23
DOIs
StatePublished - Dec 1 2021
Externally publishedYes

Keywords

  • Insulin resistance
  • Insulin sensitivity
  • Intravenous glucose tolerance test
  • Spinal cord injury
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

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