Comparison of two methods for composite score generation in dry eye syndrome

Craig See, Richard A. Bilonick, William J Feuer, Anat Galor

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose. To compare two methods of composite score generation in dry eye syndrome (DES). Methods. Male patients seen in the Miami Veterans Affairs eye clinic with normal eyelid, corneal, and conjunctival anatomy were recruited to participate in the study. Patients filled out the Dry Eye Questionnaire 5 (DEQ5) and underwent measurement of tear film parameters. DES severity scores were generated by independent component analysis (ICA) and latent class analysis (LCA). Results. A total of 247 men were included in the study. Mean age was 69 years (SD 9). Using ICA analysis, osmolarity was found to carry the largest weight, followed by eyelid vascularity and meibomian orifice plugging. Conjunctival injection and tear breakup time (TBUT) carried the lowest weights. Using LCA analysis, TBUT was found to be best at discriminating healthy from diseased eyes, followed closely by Schirmer's test. DEQ5, eyelid vascularity, and conjunctival injection were the poorest at discrimination. The adjusted correlation coefficient between the two generated composite scores was 0.63, indicating that the shared variance was less than 40%. Conclusions. Both ICA and LCA produced composite scores for dry eye severity, with weak to moderate agreement; however, agreement for the relative importance of single diagnostic tests was poor between the two methods.

Original languageEnglish
Pages (from-to)6280-6286
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume54
Issue number9
DOIs
StatePublished - Sep 19 2013

Fingerprint

Dry Eye Syndromes
Eyelids
Tears
Weights and Measures
Injections
Eye Diseases
Veterans
Routine Diagnostic Tests
Osmolar Concentration
Anatomy

Keywords

  • Composite score
  • Dry eye syndrome
  • Independent components analysis
  • Latent class analysis

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Comparison of two methods for composite score generation in dry eye syndrome. / See, Craig; Bilonick, Richard A.; Feuer, William J; Galor, Anat.

In: Investigative Ophthalmology and Visual Science, Vol. 54, No. 9, 19.09.2013, p. 6280-6286.

Research output: Contribution to journalArticle

See, Craig ; Bilonick, Richard A. ; Feuer, William J ; Galor, Anat. / Comparison of two methods for composite score generation in dry eye syndrome. In: Investigative Ophthalmology and Visual Science. 2013 ; Vol. 54, No. 9. pp. 6280-6286.
@article{3cbb7a1865a34f30a48f56b19d223451,
title = "Comparison of two methods for composite score generation in dry eye syndrome",
abstract = "Purpose. To compare two methods of composite score generation in dry eye syndrome (DES). Methods. Male patients seen in the Miami Veterans Affairs eye clinic with normal eyelid, corneal, and conjunctival anatomy were recruited to participate in the study. Patients filled out the Dry Eye Questionnaire 5 (DEQ5) and underwent measurement of tear film parameters. DES severity scores were generated by independent component analysis (ICA) and latent class analysis (LCA). Results. A total of 247 men were included in the study. Mean age was 69 years (SD 9). Using ICA analysis, osmolarity was found to carry the largest weight, followed by eyelid vascularity and meibomian orifice plugging. Conjunctival injection and tear breakup time (TBUT) carried the lowest weights. Using LCA analysis, TBUT was found to be best at discriminating healthy from diseased eyes, followed closely by Schirmer's test. DEQ5, eyelid vascularity, and conjunctival injection were the poorest at discrimination. The adjusted correlation coefficient between the two generated composite scores was 0.63, indicating that the shared variance was less than 40{\%}. Conclusions. Both ICA and LCA produced composite scores for dry eye severity, with weak to moderate agreement; however, agreement for the relative importance of single diagnostic tests was poor between the two methods.",
keywords = "Composite score, Dry eye syndrome, Independent components analysis, Latent class analysis",
author = "Craig See and Bilonick, {Richard A.} and Feuer, {William J} and Anat Galor",
year = "2013",
month = "9",
day = "19",
doi = "10.1167/iovs.13-12150",
language = "English",
volume = "54",
pages = "6280--6286",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "9",

}

TY - JOUR

T1 - Comparison of two methods for composite score generation in dry eye syndrome

AU - See, Craig

AU - Bilonick, Richard A.

AU - Feuer, William J

AU - Galor, Anat

PY - 2013/9/19

Y1 - 2013/9/19

N2 - Purpose. To compare two methods of composite score generation in dry eye syndrome (DES). Methods. Male patients seen in the Miami Veterans Affairs eye clinic with normal eyelid, corneal, and conjunctival anatomy were recruited to participate in the study. Patients filled out the Dry Eye Questionnaire 5 (DEQ5) and underwent measurement of tear film parameters. DES severity scores were generated by independent component analysis (ICA) and latent class analysis (LCA). Results. A total of 247 men were included in the study. Mean age was 69 years (SD 9). Using ICA analysis, osmolarity was found to carry the largest weight, followed by eyelid vascularity and meibomian orifice plugging. Conjunctival injection and tear breakup time (TBUT) carried the lowest weights. Using LCA analysis, TBUT was found to be best at discriminating healthy from diseased eyes, followed closely by Schirmer's test. DEQ5, eyelid vascularity, and conjunctival injection were the poorest at discrimination. The adjusted correlation coefficient between the two generated composite scores was 0.63, indicating that the shared variance was less than 40%. Conclusions. Both ICA and LCA produced composite scores for dry eye severity, with weak to moderate agreement; however, agreement for the relative importance of single diagnostic tests was poor between the two methods.

AB - Purpose. To compare two methods of composite score generation in dry eye syndrome (DES). Methods. Male patients seen in the Miami Veterans Affairs eye clinic with normal eyelid, corneal, and conjunctival anatomy were recruited to participate in the study. Patients filled out the Dry Eye Questionnaire 5 (DEQ5) and underwent measurement of tear film parameters. DES severity scores were generated by independent component analysis (ICA) and latent class analysis (LCA). Results. A total of 247 men were included in the study. Mean age was 69 years (SD 9). Using ICA analysis, osmolarity was found to carry the largest weight, followed by eyelid vascularity and meibomian orifice plugging. Conjunctival injection and tear breakup time (TBUT) carried the lowest weights. Using LCA analysis, TBUT was found to be best at discriminating healthy from diseased eyes, followed closely by Schirmer's test. DEQ5, eyelid vascularity, and conjunctival injection were the poorest at discrimination. The adjusted correlation coefficient between the two generated composite scores was 0.63, indicating that the shared variance was less than 40%. Conclusions. Both ICA and LCA produced composite scores for dry eye severity, with weak to moderate agreement; however, agreement for the relative importance of single diagnostic tests was poor between the two methods.

KW - Composite score

KW - Dry eye syndrome

KW - Independent components analysis

KW - Latent class analysis

UR - http://www.scopus.com/inward/record.url?scp=84884556004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884556004&partnerID=8YFLogxK

U2 - 10.1167/iovs.13-12150

DO - 10.1167/iovs.13-12150

M3 - Article

C2 - 23942971

AN - SCOPUS:84884556004

VL - 54

SP - 6280

EP - 6286

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 9

ER -