Comparison of two antibiotic regimens in the treatment of perforated appendicitis in pediatric patients

J. C. Rodriguez, D. Buckner, S. Schoenike, Orlando W Gomez-Marin, C. Oiticica, W. R. Thompson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and purpose: An increased incidence of post-surgical infectious complications in children admitted with a diagnosis of perforated appendicitis led to development of a disease-specific antibiogram and modification of our post-operative antibiotic regimen. Methods: A historical control group comprised of 32 pediatric patients receiving ampicillin, gentamicin, and clindamycin (group AGC) was compared to a cohort of 32 children receiving ticarcillin/clavulanate plus gentamicin (group TG). The surgical procedure, peri-operative management, and inclusion, exclusion and discharge criteria were the same for each group. Outcome measures including length of stay, time to defervesce, incidence of infectious complications, and clinical failures to the antibiotic regimen were compared. Results: The groups were similar with respect to gender, age, weight, surgical time, pre-operative leukocytes, and number of intra-operative bacterial isolates cultured per patient. Length of stay was 10.1 days in group TG and 12.5 days for group AGC (p = 0.0197). The number of clinical failures was reduced from 9 (28.1%) to 2 (6.3%) in group TG (p = 0.02). The time to defervesce was decreased by 1.4 days, and the number of infectious complications was reduced to 2.5-fold in group TG patients. Conclusions: Ticarcillin/clavulanate plus gentamicin was clinically more effective than ampicillin, gentamicin, and clindamycin combination therapy in the management of perforated appendicitis in our pediatric population.

Original languageEnglish
Pages (from-to)492-499
Number of pages8
JournalInternational Journal of Clinical Pharmacology and Therapeutics
Volume38
Issue number10
StatePublished - Oct 23 2000

Fingerprint

Pediatrics
Appendicitis
Gentamicins
Ticarcillin
Anti-Bacterial Agents
Clavulanic Acid
Clindamycin
Ampicillin
Length of Stay
Incidence
Operative Surgical Procedures
Microbial Sensitivity Tests
Therapeutics
Operative Time
Leukocyte Count
Outcome Assessment (Health Care)
Weights and Measures
Control Groups
Population

Keywords

  • Ampicillin
  • Antimicrobial therapy
  • Clindamycin
  • Escherichia coli
  • Gentamicin
  • Pediatrics
  • Perforated appendicitis
  • Pseudomonas aeruginosa
  • Ticarcillin/ clavulanate

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Rodriguez, J. C., Buckner, D., Schoenike, S., Gomez-Marin, O. W., Oiticica, C., & Thompson, W. R. (2000). Comparison of two antibiotic regimens in the treatment of perforated appendicitis in pediatric patients. International Journal of Clinical Pharmacology and Therapeutics, 38(10), 492-499.

Comparison of two antibiotic regimens in the treatment of perforated appendicitis in pediatric patients. / Rodriguez, J. C.; Buckner, D.; Schoenike, S.; Gomez-Marin, Orlando W; Oiticica, C.; Thompson, W. R.

In: International Journal of Clinical Pharmacology and Therapeutics, Vol. 38, No. 10, 23.10.2000, p. 492-499.

Research output: Contribution to journalArticle

Rodriguez, JC, Buckner, D, Schoenike, S, Gomez-Marin, OW, Oiticica, C & Thompson, WR 2000, 'Comparison of two antibiotic regimens in the treatment of perforated appendicitis in pediatric patients', International Journal of Clinical Pharmacology and Therapeutics, vol. 38, no. 10, pp. 492-499.
Rodriguez, J. C. ; Buckner, D. ; Schoenike, S. ; Gomez-Marin, Orlando W ; Oiticica, C. ; Thompson, W. R. / Comparison of two antibiotic regimens in the treatment of perforated appendicitis in pediatric patients. In: International Journal of Clinical Pharmacology and Therapeutics. 2000 ; Vol. 38, No. 10. pp. 492-499.
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