Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer

Niramol Savaraj, Rong Xu, Howard Landy, Shenghan Lai, Linda Sternau, Jeannine Solomon, Chun Jing Wu, Theodore Lampidis, Lynn G Feun

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Topoisomerase I (TOP I) and II (TOP II) activities and their corresponding levels were analyzed in 27 primary brain tumors and 32 lung cancers (28 NSCLC, 4 SCLC). The TOP I and II activities in primary brain tumors varied from 500-2,000 units/mg and 100-3,000 units/mg respectively. Their corresponding levels varied from <0.01-3.30 (TOP I) and 0.24-8.30 (TOP II) arbitrary units. In lung cancer, the TOP I and II activities ranged from 1,000-4,000 and 5004,000 units/mg respectively with their levels ranging from 0.30-61.60 and 0.2-14.2 arbitrary units respectively. These parameters were compared in both tumors using the Wilcoxon rank sums test, the difference were statically significance for all four parameters with a p<0.0001 for TOP I and II activities and TOP I levels and p<0.09 for TOP II levels. Using linear regression analysis, there was no correlation between TOP I and II activities and their corresponding levels in primary brain tumor. However, in lung cancer, the relationship between TOP I activities and levels were linear with r2=0.2 and p<0.0094, but not for TOP II activity and their levels. There was no relationship between TOP I and TOP II levels in the same tumor for both types of cancer. The future clinical implication of these findings are discussed.

Original languageEnglish
Pages (from-to)857-861
Number of pages5
JournalOncology Reports
Volume4
Issue number4
StatePublished - Jul 1 1997

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Type II DNA Topoisomerase
Type I DNA Topoisomerase
Brain Neoplasms
Lung Neoplasms
Nonparametric Statistics
Neoplasms
Linear Models
Regression Analysis

Keywords

  • Brain tumor
  • Lung cancer
  • Topoisomerase I and II

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer. / Savaraj, Niramol; Xu, Rong; Landy, Howard; Lai, Shenghan; Sternau, Linda; Solomon, Jeannine; Wu, Chun Jing; Lampidis, Theodore; Feun, Lynn G.

In: Oncology Reports, Vol. 4, No. 4, 01.07.1997, p. 857-861.

Research output: Contribution to journalArticle

Savaraj, Niramol ; Xu, Rong ; Landy, Howard ; Lai, Shenghan ; Sternau, Linda ; Solomon, Jeannine ; Wu, Chun Jing ; Lampidis, Theodore ; Feun, Lynn G. / Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer. In: Oncology Reports. 1997 ; Vol. 4, No. 4. pp. 857-861.
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