Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer

Niramol Savaraj, Rong Xu, Howard Landy, Shenghan Lai, Linda Sternau, Jeannine Solomon, Chun Jing Wu, Theodore Lampidis, Lynn G. Feun

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Topoisomerase I (TOP I) and II (TOP II) activities and their corresponding levels were analyzed in 27 primary brain tumors and 32 lung cancers (28 NSCLC, 4 SCLC). The TOP I and II activities in primary brain tumors varied from 500-2,000 units/mg and 100-3,000 units/mg respectively. Their corresponding levels varied from <0.01-3.30 (TOP I) and 0.24-8.30 (TOP II) arbitrary units. In lung cancer, the TOP I and II activities ranged from 1,000-4,000 and 5004,000 units/mg respectively with their levels ranging from 0.30-61.60 and 0.2-14.2 arbitrary units respectively. These parameters were compared in both tumors using the Wilcoxon rank sums test, the difference were statically significance for all four parameters with a p<0.0001 for TOP I and II activities and TOP I levels and p<0.09 for TOP II levels. Using linear regression analysis, there was no correlation between TOP I and II activities and their corresponding levels in primary brain tumor. However, in lung cancer, the relationship between TOP I activities and levels were linear with r2=0.2 and p<0.0094, but not for TOP II activity and their levels. There was no relationship between TOP I and TOP II levels in the same tumor for both types of cancer. The future clinical implication of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
JournalOncology Reports
Volume4
Issue number4
DOIs
StatePublished - 1997

Keywords

  • Brain tumor
  • Lung cancer
  • Topoisomerase I and II

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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