Comparison of the tissue penetration and glide force of 22-gauge thin-wall needles for intravitreal implant administration

Sophie J. Bakri, David S. Boyer, Thomas A. Albini, Nancy M. Holekamp, Philip J. Ferrone, Rahul Bhagat, Zoran Novakovic

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND OBJECTIVE: To identify a needle to improve intravitreal dexamethasone implant administration by evaluating ease of ocular tissue penetration and glide force, key characteristics of needle performance. MATERIALS AND METHODS: Two custom-applicator needles coated with distinct lubricants (needles A and B) and the original dexamethasone implant needle were evaluated by five retina specialists. Ex vivo porcine eyes were injected, and a visual analog scale was used in ratings. RESULTS: Ease of ocular tissue penetration and glide force of needle B were rated significantly higher than that of the original applicator needle (P < .001), but there were no significant differences for needle A. Lot to lot, needle B was not significantly different in penetration and glide, whereas a significant difference was observed for penetration of needle A (P = .043). CONCLUSION : Needle design and lubricant appear to facilitate penetration and reduce glide force when administering dexamethasone intravitreal implants. Minimal lot-to-lot variation should be considered in needle choice.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume45
Issue number5
DOIs
StatePublished - Sep 1 2014

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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