Comparison of the inhibition of histamine-and pentagastrin-stimulated gastric acid secretion by somatostatin in the cat

Margitta Albinus, J. David Reed, Antonio Gomez-Pan, Andrew V. Schally, David H. Coy

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The effect of cyclic somatostatin on pentagastrin-and histamine-stimulated gastric acid secretion in conscious cats was studied. Evidence is produced that somatostatin competitively inhibits pentagastrin-stimulated gastric acid secretion whereas it inhibits histamine-stimulated secretion by a mechanism which is not competitive in nature. The vagus nerves seem to be involved in the mode of action of somatostatin as the inhibitory effects are greater in vagotomized than in vagus intact animals.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalAgents and Actions
Volume7
Issue number5-6
DOIs
StatePublished - Dec 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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