Comparison of the electrocardiographic effect of dothiepin and amitriptyline

J. L. Claghorn, J. Schroeder, B. J. Goldstein

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Abstract

Electrocardiograms of 65 patients treated with dothiepin, a sulphur substituted tricyclic antidepressant, were compared to those of 57 patients receiving amitriptyline and 62 patients given placebo. Amitriptyline produced an average heart rate increase of 10 beats/minute as compared to 5 beats/minute for dothiepin (p < .02). Amitriptyline also produced a significant prolongation of the corrected QT interval as compared to both dothiepin and placebo (p < .01 and p < .001, respectively). Dothiepin had no significant effect on any index of myocardial conduction (PR interval, corrected QT interval, and QRS duration) as compared to placebo.

Original languageEnglish (US)
Pages (from-to)291-293
Number of pages3
JournalJournal of Clinical Psychiatry
Volume45
Issue number7 I
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Claghorn, J. L., Schroeder, J., & Goldstein, B. J. (1984). Comparison of the electrocardiographic effect of dothiepin and amitriptyline. Journal of Clinical Psychiatry, 45(7 I), 291-293.