Abstract
Electrocardiograms of 65 patients treated with dothiepin, a sulphur substituted tricyclic antidepressant, were compared to those of 57 patients receiving amitriptyline and 62 patients given placebo. Amitriptyline produced an average heart rate increase of 10 beats/minute as compared to 5 beats/minute for dothiepin (p < .02). Amitriptyline also produced a significant prolongation of the corrected QT interval as compared to both dothiepin and placebo (p < .01 and p < .001, respectively). Dothiepin had no significant effect on any index of myocardial conduction (PR interval, corrected QT interval, and QRS duration) as compared to placebo.
Original language | English (US) |
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Pages (from-to) | 291-293 |
Number of pages | 3 |
Journal | Journal of Clinical Psychiatry |
Volume | 45 |
Issue number | 7 I |
State | Published - Jan 1 1984 |
ASJC Scopus subject areas
- Psychiatry and Mental health