Abstract
Electrocardiograms of 65 patients treated with dothiepin, a sulphur substituted tricyclic antidepressant, were compared to those of 57 patients receiving amitriptyline and 62 patients given placebo. Amitriptyline produced an average heart rate increase of 10 beats/minute as compared to 5 beats/minute for dothiepin (p < .02). Amitriptyline also produced a significant prolongation of the corrected QT interval as compared to both dothiepin and placebo (p < .01 and p < .001, respectively). Dothiepin had no significant effect on any index of myocardial conduction (PR interval, corrected QT interval, and QRS duration) as compared to placebo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 291-293 |
| Number of pages | 3 |
| Journal | Journal of Clinical Psychiatry |
| Volume | 45 |
| Issue number | 7 I |
| State | Published - Jan 1 1984 |
ASJC Scopus subject areas
- Psychiatry and Mental health
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Claghorn, J. L., Schroeder, J., & Goldstein, B. J. (1984). Comparison of the electrocardiographic effect of dothiepin and amitriptyline. Journal of Clinical Psychiatry, 45(7 I), 291-293.