Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anesthetized cat and on the isolated cat pancreas

M. Albinus, E. L. Blair, R. M. Case, D. H. Coy, A. Gomez-Pan, B. H. Hirst, J. D. Reed, Andrew V Schally, B. Shaw, P. A. Smith, J. R. Smy

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Somatostatin, 10 μg kg -1 hr -1, inhibited gastric acid and pepsin secretion stimulated by pentagastrin, 8 μg kg -1 hr -1, in conscious and anaesthetized cats with chronically implanted gastric fistulae. In the acutely surgically prepared anaesthetized cat, Somatostatin inhibited pepsin secretion but produced little inhibition of gastric secretion or mucosal blood flow. Secretin stimulated pancreatic juice volume was not significantly reduced in acutely prepared anaesthetized cats, but there was a limited reduction of cholecystokinin-pancreozymin stimulated pancreatic amylase secretion and gall bladder contraction. Somatostatin had neither stimulatory nor inhibitory effects on electrolyte and amylase secretion in the isolated saline-perfused cat pancreas. The results suggest that some of the effects of Somatostatin may depend on the interaction on the target cell of other factors, nervous or humoral, which may vary in different experimental preparations.

Original languageEnglish
Pages (from-to)77-91
Number of pages15
JournalJournal of Physiology
Volume269
Issue number1
StatePublished - Dec 1 1977
Externally publishedYes

Fingerprint

Somatostatin
Pancreas
Cats
Pepsin A
Cholecystokinin
Amylases
Gastric Fistula
Pancreatic Juice
Pentagastrin
Secretin
Gastric Acid
Electrolytes
Stomach
Urinary Bladder

ASJC Scopus subject areas

  • Physiology

Cite this

Albinus, M., Blair, E. L., Case, R. M., Coy, D. H., Gomez-Pan, A., Hirst, B. H., ... Smy, J. R. (1977). Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anesthetized cat and on the isolated cat pancreas. Journal of Physiology, 269(1), 77-91.

Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anesthetized cat and on the isolated cat pancreas. / Albinus, M.; Blair, E. L.; Case, R. M.; Coy, D. H.; Gomez-Pan, A.; Hirst, B. H.; Reed, J. D.; Schally, Andrew V; Shaw, B.; Smith, P. A.; Smy, J. R.

In: Journal of Physiology, Vol. 269, No. 1, 01.12.1977, p. 77-91.

Research output: Contribution to journalArticle

Albinus, M, Blair, EL, Case, RM, Coy, DH, Gomez-Pan, A, Hirst, BH, Reed, JD, Schally, AV, Shaw, B, Smith, PA & Smy, JR 1977, 'Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anesthetized cat and on the isolated cat pancreas', Journal of Physiology, vol. 269, no. 1, pp. 77-91.
Albinus, M. ; Blair, E. L. ; Case, R. M. ; Coy, D. H. ; Gomez-Pan, A. ; Hirst, B. H. ; Reed, J. D. ; Schally, Andrew V ; Shaw, B. ; Smith, P. A. ; Smy, J. R. / Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anesthetized cat and on the isolated cat pancreas. In: Journal of Physiology. 1977 ; Vol. 269, No. 1. pp. 77-91.
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