Comparison of the anticholinergic bronchodilator ipratropium bromide with metaproterenol in chronic obstructive pulmonary disease: A 90-day multi-center study

Donald P. Tashkin, Kumar Ashutosh, Eugene R. Bleecker, E. James Britt, David W. Cugell, Joseph M. Cummiskey, Lawrence Delorenzo, Murray J. Gilman, Gary N. Gross, Nicholas J. Gross, Arthur Kotch, Sambasiva Lakshminarayan, George Maguire, Matthew Miller, Alan Plummer, Attilio Renzetti, Marvin A. Sackner, Morton S. Skoroqin, Adam Wanner, Suetaro Watanabe

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

The short- and long-term efficacy and safety of an inhaled quaternary ammonium anticholinergic agent, ipratropium bromide, and a beta agonist aerosol, metaproterenol, were compared in 261 non-atopic patients with chronic obstructive pulmonary disease (COPD). The study was a randomized, double-blind, 90-day, parallel-group trial. On three test days-one, 45, and 90-mean peak responses for forced expiratory volume in one second and forced vital capacity and mean area under the time-response curve were higher for ipratropium than for metaproterenol. Clinical improvement was noted in both treatment groups, especially during the first treatment month, with persistence of improvement throughout the remainder of the study. Side effects were relatively infrequent and generally mild; tremor, a complication of beta agonists, was not reported by any subject receiving ipratropium. These results support the effectiveness and safety of long-term treatment with inhaled ipratropium in COPD.

Original languageEnglish (US)
Pages (from-to)81-90
Number of pages10
JournalThe American journal of medicine
Volume81
Issue number5 SUPPL. 1
DOIs
StatePublished - Nov 14 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Tashkin, D. P., Ashutosh, K., Bleecker, E. R., Britt, E. J., Cugell, D. W., Cummiskey, J. M., Delorenzo, L., Gilman, M. J., Gross, G. N., Gross, N. J., Kotch, A., Lakshminarayan, S., Maguire, G., Miller, M., Plummer, A., Renzetti, A., Sackner, M. A., Skoroqin, M. S., Wanner, A., & Watanabe, S. (1986). Comparison of the anticholinergic bronchodilator ipratropium bromide with metaproterenol in chronic obstructive pulmonary disease: A 90-day multi-center study. The American journal of medicine, 81(5 SUPPL. 1), 81-90. https://doi.org/10.1016/0002-9343(86)90468-7