Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of [p-phe2, d-leu6]-LH-RH and [o-phe2, d-ala6]-LH-RH

J. A. Vilchez-Martinez, D. H. Coy, E. J. Coy, A. Arimura, A. V. Schally

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17 Scopus citations

Abstract

The anti-LH/FSH-RH and antiovulatory activities of [D-Phe2, D-Leu6]-LH-RH and [D-Phe2, D-Ala6]-LH-RH were compared in rats. Both peptides inhibited the LH and FSH release induced by LH-RH in immature male rats, but, 4 hr after the injection, [D-Phe2, D-Leu6]-LH-RH still suppressed the LH and FSH release whereas the [D-Phe2, D-Ala6]-LH-RH did not. When the peptides were administered in equal doses on the afternoon of the day of proestrus in 4-day cycling rats, [D-Phe2, D-Leu6]-LH-RH more completely inhibited the ovulation occurring on the following morning than [D-Phe2, D-Ala6]-LH-RH. Thus, the incorporation of D-Leucine into position six of the decapeptide chain gives a more potent inhibitor than that resulting from the insertion of D-Alanine.

Original languageEnglish (US)
Pages (from-to)231-241
Number of pages11
JournalEndocrine Research
Volume3
Issue number3-4
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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