Comparison of the analeptic potency of TRH, ACTH 4-10, LHRH, and related peptides

Garth Bissette, Charles Nemeroff, Peter T. Loosen, Arthur J. Prange, Morris A. Lipton

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Various peptide hormones appear to exert behavioral and pharmacologic effects apart from their classical endocrine actions. Thyrotropin-releasing hormone (TRH), for example, antagonizes the sedation and hypothermia produced by barbiturate and other depressant drugs and de Wied has shown that ACTH 4-10, TRH, LHRH and certain related substances show some activity in inhibition of extinction of a pole-jumping avoidance response in the rat. These data provided the impetus for screening ACTH 4-10, LHRH, and related peptides for analeptic activity. ACTH 4-10 and ACTH 4-7 were inactive in antagonizing pentobarbital whether administered peripherally or centrally. ACTH 4-7 amide and 4-Met(O2),8-D-Lys,9-Phe-ACTH 4-9 were active regardless of route of administration LHRH and two tripeptide fragments (Glu-His-Trp-NH2 and pGlu-His-Phe-NH2) showed analeptic activity only after intracisternal administration. Thus, sme peptide fragments related to ACTH 4-10 and LHRH were shown to share were shown to share to some degree the analeptic properties previously demonstrated for TRH.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume5
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

Fingerprint

ACTH (4-10)
Central Nervous System Stimulants
Thyrotropin-Releasing Hormone
Gonadotropin-Releasing Hormone
Peptides
Hypothermia
Peptide Fragments
Peptide Hormones
Pentobarbital
Amides
Rats
Poles
Screening
Pharmaceutical Preparations

Keywords

  • ACTH peptides
  • Luteinizing hormone-releasing hormone
  • Sodium pentobarbital
  • Thyrotropin releasing hormone

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Comparison of the analeptic potency of TRH, ACTH 4-10, LHRH, and related peptides. / Bissette, Garth; Nemeroff, Charles; Loosen, Peter T.; Prange, Arthur J.; Lipton, Morris A.

In: Pharmacology, Biochemistry and Behavior, Vol. 5, No. SUPPL. 1, 01.01.1976, p. 135-138.

Research output: Contribution to journalArticle

Bissette, Garth ; Nemeroff, Charles ; Loosen, Peter T. ; Prange, Arthur J. ; Lipton, Morris A. / Comparison of the analeptic potency of TRH, ACTH 4-10, LHRH, and related peptides. In: Pharmacology, Biochemistry and Behavior. 1976 ; Vol. 5, No. SUPPL. 1. pp. 135-138.
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