Comparison of the analeptic potency of TRH, ACTH 4-10, LHRH, and related peptides

Garth Bissette, Charles B. Nemeroff, Peter T. Loosen, Arthur J. Prange, Morris A. Lipton

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Various peptide hormones appear to exert behavioral and pharmacologic effects apart from their classical endocrine actions. Thyrotropin-releasing hormone (TRH), for example, antagonizes the sedation and hypothermia produced by barbiturate and other depressant drugs and de Wied has shown that ACTH 4-10, TRH, LHRH and certain related substances show some activity in inhibition of extinction of a pole-jumping avoidance response in the rat. These data provided the impetus for screening ACTH 4-10, LHRH, and related peptides for analeptic activity. ACTH 4-10 and ACTH 4-7 were inactive in antagonizing pentobarbital whether administered peripherally or centrally. ACTH 4-7 amide and 4-Met(O2),8-D-Lys,9-Phe-ACTH 4-9 were active regardless of route of administration LHRH and two tripeptide fragments (Glu-His-Trp-NH2 and pGlu-His-Phe-NH2) showed analeptic activity only after intracisternal administration. Thus, sme peptide fragments related to ACTH 4-10 and LHRH were shown to share were shown to share to some degree the analeptic properties previously demonstrated for TRH.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume5
Issue numberSUPPL. 1
DOIs
StatePublished - 1976
Externally publishedYes

Keywords

  • ACTH peptides
  • Luteinizing hormone-releasing hormone
  • Sodium pentobarbital
  • Thyrotropin releasing hormone

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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