Comparison of spectral fitting methods for overlapping j-coupled metabolite resonances

A. Gonenc, V. Govind, S. Sheriff, Andrew A. Maudsley

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


There is increasing interest in the use of two-dimensional J-resolved spectroscopic acquisition (multiecho) methods for in vivo proton magnetic resonance spectroscopy due to the improved discrimination of overlapping J-coupled multiplet resonances that is provided. Of particular interest is the potential for discrimination of the overlapping resonances of glutamate and glutamine. In this study, a new time-domain parametric spectral model that makes use of all available data is described for fitting the complete two-dimensional multi-echo data, and the performance of this method was compared with fitting of one-dimensional spectra obtained following averaging multiecho data (echo time-averaged) and single-echo time PRESS (Point Resolved Spectroscopy) acquired spectra. These methods were compared using data obtained from a phantom containing typical brain metabolites and a human brain. Results indicate that improved performance and accuracy is obtained for the two-dimensional acquisition and spectral fitting model.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Sep 2010


  • Brain
  • Glutamate
  • Glutamine
  • In vivo proton MR spectroscopy
  • Spectral analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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