Comparison of Single-Session Dose Response Effects of Whole Body Vibration on Spasticity and Walking Speed in Persons with Spinal Cord Injury

Stephen Estes, Jennifer A. Iddings, Somu Ray, Neva J Kirk-Sanchez, Edelle C. Field-Fote

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Spasticity affects approximately 65% of persons with spinal cord injury (SCI) and negatively impacts function and quality of life. Whole body vibration (WBV) appears to reduce spasticity and improve walking function; however, the optimal dose (frequency/duration) is not known. We compared single-session effects of four different WBV frequency/duration dose conditions on spasticity and walking speed, in preparation for a planned multi-session study. Thirty-five participants with motor-incomplete SCI received four different doses of WBV: high frequency (50 Hz)/short duration (180 s), high frequency/long duration (360 s), low frequency (30 Hz)/short duration, and low frequency/long duration, plus a control intervention consisting of sham electrical stimulation. In all conditions, participants stood on the WBV platform for 45-s bouts with 1 min rest between bouts until the requisite duration was achieved. The frequency/duration dose order was randomized across participants; sessions were separated by at least 1 week. Quadriceps spasticity was measured using the pendulum test at four time points during each session: before, immediately after, 15 min after, and 45 min after WBV. Walking speed was quantified using the 10-m walk test at three time points during each session: baseline, immediately after, and 45 min after WBV. In the full group analysis, no frequency/duration combination was significantly different from the sham-control condition. In participants with more severe spasticity, a greater reduction in stretch reflex excitability was associated with the high frequency/long duration WBV condition. The sham-control condition was associated with effects, indicating that the activity of repeated sitting and standing may have a beneficial influence on spasticity. Trial registration: NCT02340910 (assigned 01/19/2015).

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalNeurotherapeutics
DOIs
StateAccepted/In press - Jun 29 2018

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Vibration
Spinal Cord Injuries
Stretch Reflex
Walking Speed
Electric Stimulation
Walking
Quality of Life

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Comparison of Single-Session Dose Response Effects of Whole Body Vibration on Spasticity and Walking Speed in Persons with Spinal Cord Injury. / Estes, Stephen; Iddings, Jennifer A.; Ray, Somu; Kirk-Sanchez, Neva J; Field-Fote, Edelle C.

In: Neurotherapeutics, 29.06.2018, p. 1-13.

Research output: Contribution to journalArticle

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