TY - JOUR
T1 - Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration
AU - Zheng, Fang
AU - Zhang, Qinqin
AU - Motulsky, Elie H.
AU - de Oliveira Dias, João Rafael
AU - Chen, Chieh Li
AU - Chu, Zhongdi
AU - Miller, Andrew R.
AU - Feuer, William
AU - Gregori, Giovanni
AU - Kubach, Sophie
AU - Durbin, Mary K.
AU - Wang, Ruikang K.
AU - Rosenfeld, Philip J.
N1 - Funding Information:
Supported by grants from Carl Zeiss Meditec, Inc. (Dublin, CA, USA), the National Eye Institute (R01EY024158), an unrestricted grant from the Research to Prevent Blindness, Inc., New York, NY, USA, and the National Eye Institute Center Core Grant (P30EY014801) to the Department of Ophthalmology, University of Miami Miller School of Medicine. Disclosure: F. Zheng, None; Q. Zhang, None; E.H. Motulsky, None; J.R. de Oliveira Dias, None; C.-L. Chen, None; Z. Chu, None; A.R. Miller, None; W. Feuer, None; G. Gregori, Carl Zeiss Meditec (F), P; S. Kubach, Carl Zeiss Meditec (E); M.K. Durbin, Carl Zeiss Meditec (E); R.K. Wang, Carl Zeiss Meditec (F), Tasso, Inc. (F), Insight Photonic Solutions (C), Westface Medical (C), Kowa (C), P; P.J. Rosenfeld, Acucela (C, F), Alcon (C), Apellis (F, I), Boehringer-Ingelheim (C), Carl Zeiss Meditec (C, F), Cell Cure Neurosciences (C), Chengdu Kanghong Biotech (C), Digisight (I), F. Hoffmann-La Roche Ltd. (C), Genentech (C, F), GlaxoSmithKline (F), Astellas Institute for Regenerative Medicine (F), Healios K.K. (C), Hemera Biosciences (C), Isarna Pharmaceuticals (C), MacRe-gen Inc. (C), Ocudyne (C, I), Ocunexus Therapeutics (C), Tyrogenex (C, F), Unity Biotechnology (C)
Publisher Copyright:
© 2017 The Authors.
PY - 2017/10
Y1 - 2017/10
N2 - PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.
AB - PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.
KW - Choroidal neovascularization
KW - Neovascular AMD
KW - Optical coherence tomography angiography
KW - Quantified measurement comparison
KW - Swept-source OCTA
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U2 - 10.1167/iovs.17-22506
DO - 10.1167/iovs.17-22506
M3 - Article
C2 - 28986595
AN - SCOPUS:85031714892
VL - 58
SP - 5098
EP - 5104
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 12
ER -