Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration

Fang Zheng, Qinqin Zhang, Elie H. Motulsky, João Rafael de Oliveira Dias, Chieh Li Chen, Zhongdi Chu, Andrew R. Miller, William J Feuer, Giovanni Gregori, Sophie Kubach, Mary K. Durbin, Ruikang K. Wang, Philip J Rosenfeld

Research output: Contribution to journalArticle

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Abstract

PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.

Original languageEnglish (US)
Pages (from-to)5098-5104
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume58
Issue number12
DOIs
StatePublished - Oct 1 2017

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Optical Coherence Tomography
Macular Degeneration
Angiography
Analysis of Variance
Choroidal Neovascularization

Keywords

  • Choroidal neovascularization
  • Neovascular AMD
  • Optical coherence tomography angiography
  • Quantified measurement comparison
  • Swept-source OCTA

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration. / Zheng, Fang; Zhang, Qinqin; Motulsky, Elie H.; de Oliveira Dias, João Rafael; Chen, Chieh Li; Chu, Zhongdi; Miller, Andrew R.; Feuer, William J; Gregori, Giovanni; Kubach, Sophie; Durbin, Mary K.; Wang, Ruikang K.; Rosenfeld, Philip J.

In: Investigative Ophthalmology and Visual Science, Vol. 58, No. 12, 01.10.2017, p. 5098-5104.

Research output: Contribution to journalArticle

Zheng, F, Zhang, Q, Motulsky, EH, de Oliveira Dias, JR, Chen, CL, Chu, Z, Miller, AR, Feuer, WJ, Gregori, G, Kubach, S, Durbin, MK, Wang, RK & Rosenfeld, PJ 2017, 'Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration', Investigative Ophthalmology and Visual Science, vol. 58, no. 12, pp. 5098-5104. https://doi.org/10.1167/iovs.17-22506
Zheng, Fang ; Zhang, Qinqin ; Motulsky, Elie H. ; de Oliveira Dias, João Rafael ; Chen, Chieh Li ; Chu, Zhongdi ; Miller, Andrew R. ; Feuer, William J ; Gregori, Giovanni ; Kubach, Sophie ; Durbin, Mary K. ; Wang, Ruikang K. ; Rosenfeld, Philip J. / Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration. In: Investigative Ophthalmology and Visual Science. 2017 ; Vol. 58, No. 12. pp. 5098-5104.
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abstract = "PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.",
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T1 - Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration

AU - Zheng, Fang

AU - Zhang, Qinqin

AU - Motulsky, Elie H.

AU - de Oliveira Dias, João Rafael

AU - Chen, Chieh Li

AU - Chu, Zhongdi

AU - Miller, Andrew R.

AU - Feuer, William J

AU - Gregori, Giovanni

AU - Kubach, Sophie

AU - Durbin, Mary K.

AU - Wang, Ruikang K.

AU - Rosenfeld, Philip J

PY - 2017/10/1

Y1 - 2017/10/1

N2 - PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.

AB - PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.

KW - Choroidal neovascularization

KW - Neovascular AMD

KW - Optical coherence tomography angiography

KW - Quantified measurement comparison

KW - Swept-source OCTA

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