Abstract
PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5098-5104 |
| Number of pages | 7 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 58 |
| Issue number | 12 |
| DOIs | |
| State | Published - Oct 1 2017 |
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Keywords
- Choroidal neovascularization
- Neovascular AMD
- Optical coherence tomography angiography
- Quantified measurement comparison
- Swept-source OCTA
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration. / Zheng, Fang; Zhang, Qinqin; Motulsky, Elie H.; de Oliveira Dias, João Rafael; Chen, Chieh Li; Chu, Zhongdi; Miller, Andrew R.; Feuer, William J; Gregori, Giovanni; Kubach, Sophie; Durbin, Mary K.; Wang, Ruikang K.; Rosenfeld, Philip J.
In: Investigative Ophthalmology and Visual Science, Vol. 58, No. 12, 01.10.2017, p. 5098-5104.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration
AU - Zheng, Fang
AU - Zhang, Qinqin
AU - Motulsky, Elie H.
AU - de Oliveira Dias, João Rafael
AU - Chen, Chieh Li
AU - Chu, Zhongdi
AU - Miller, Andrew R.
AU - Feuer, William J
AU - Gregori, Giovanni
AU - Kubach, Sophie
AU - Durbin, Mary K.
AU - Wang, Ruikang K.
AU - Rosenfeld, Philip J
PY - 2017/10/1
Y1 - 2017/10/1
N2 - PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.
AB - PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.
KW - Choroidal neovascularization
KW - Neovascular AMD
KW - Optical coherence tomography angiography
KW - Quantified measurement comparison
KW - Swept-source OCTA
UR - http://www.scopus.com/inward/record.url?scp=85031714892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031714892&partnerID=8YFLogxK
U2 - 10.1167/iovs.17-22506
DO - 10.1167/iovs.17-22506
M3 - Article
C2 - 28986595
AN - SCOPUS:85031714892
VL - 58
SP - 5098
EP - 5104
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 12
ER -