Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration

Fang Zheng, Qinqin Zhang, Elie H. Motulsky, João Rafael de Oliveira Dias, Chieh Li Chen, Zhongdi Chu, Andrew R. Miller, William Feuer, Giovanni Gregori, Sophie Kubach, Mary K. Durbin, Ruikang K. Wang, Philip J. Rosenfeld

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

PURPOSE. We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 × 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 × 6 mm scan. RESULTS. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 × 3, 6 × 6, and 12 × 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 × 3 vs. 6 × 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 × 6, 9 × 9, and 12 × 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 × 6 vs. 9 × 9 mm; P = 0.553, 6 × 6 vs. 12 × 12 mm; P = 0.654, 9 × 9 vs. 12 × 12 mm). CONCLUSIONS. The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.

Original languageEnglish (US)
Pages (from-to)5098-5104
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume58
Issue number12
DOIs
StatePublished - Oct 2017

Keywords

  • Choroidal neovascularization
  • Neovascular AMD
  • Optical coherence tomography angiography
  • Quantified measurement comparison
  • Swept-source OCTA

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Zheng, F., Zhang, Q., Motulsky, E. H., de Oliveira Dias, J. R., Chen, C. L., Chu, Z., Miller, A. R., Feuer, W., Gregori, G., Kubach, S., Durbin, M. K., Wang, R. K., & Rosenfeld, P. J. (2017). Comparison of neovascular lesion area measurements from different swept-source OCT angiographic scan patterns in age-related macular degeneration. Investigative Ophthalmology and Visual Science, 58(12), 5098-5104. https://doi.org/10.1167/iovs.17-22506