Comparison of methodological approaches to human gut microbiota changes in response to metabolic and bariatric surgery: A systematic review

Elisa Morales-Marroquin, Blake Hanson, Leigh Greathouse, Nestor de la Cruz-Munoz, Sarah E. Messiah

Research output: Contribution to journalArticle

Abstract

Substantial differences in the response of gut microbial composition to metabolic and bariatric surgery have been reported. Therefore, the goal of the present review is to evaluate if methodological differences could be driving this lack of consistency. A search was conducted using PUBMED, Web of Science, Science Direct and COCHRANE using the following inclusion criteria: human studies written in English with a baseline sampling point, using gut microbiota as an outcome and either Roux-n-Y gastric bypass or sleeve gastrectomy. Sixteen articles were selected (total 221 participants). Roux-n-Y gastric bypass caused more alterations in gut microbial composition in comparison with sleeve gastrectomy. Substantial variability was found in study designs, data collection and analyses across studies. Increases in several families and genera from the phylum Proteobacteria and Bacteroidetes, the family Streptococcaceae, the species Akkermansia muciniphila and Streptococcus salivarius and a decrease in the phylum Firmicutes and the family Bifidobacteriaceae were reported. There is a need for standardization not only of microbial analysis but also of study designs when analysing the effect of bariatric surgery on the human gut microbiome. In addition, outcomes from different surgical procedures should not be combined as they produce distinctive effects on gut microbial composition.

Original languageEnglish (US)
Article numbere13025
JournalObesity Reviews
Volume21
Issue number8
DOIs
StatePublished - Aug 1 2020

Keywords

  • RYGB
  • bariatric surgery
  • gastric sleeve
  • gut microbiota

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

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