Comparison of inversion recovery preparation schemes for lipid suppression in 1H MRSI of human brain

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41 Scopus citations


To reduce contamination from subcutaneous lipid regions in MR spectroscopic imaging (MRSI) of whole brain, lipid signals are often suppressed using T1 nulling methods. If a range of lipid T1 values is present, the suppression efficiency will be improved using multiple inversion recovery (MIR) preparation. This study compared single IR (SIR) and double IR (DIR) applied with a volumetric MRSI sequence at 1.5 T based on experimental measurement of lipid T1 and T2 relaxation rates. At short and medium echo times (TEs), an approximately 28-47% improvement in lipid suppression was achieved with DIR compared to SIR. However, it also led to a loss of 37-43% in signal-to-noise ratio (SNR) for metabolites. Thus, SIR appears to be the better choice for suppressing lipid signals and maintaining metabolite sensitivity.

Original languageEnglish (US)
Pages (from-to)903-908
Number of pages6
JournalMagnetic Resonance in Medicine
Issue number5
StatePublished - May 1 2003


  • Brain
  • In vivo MR spectroscopic imaging
  • Inversion recovery
  • Lipid relaxation
  • Lipid suppression

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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