To reduce contamination from subcutaneous lipid regions in MR spectroscopic imaging (MRSI) of whole brain, lipid signals are often suppressed using T1 nulling methods. If a range of lipid T1 values is present, the suppression efficiency will be improved using multiple inversion recovery (MIR) preparation. This study compared single IR (SIR) and double IR (DIR) applied with a volumetric MRSI sequence at 1.5 T based on experimental measurement of lipid T1 and T2 relaxation rates. At short and medium echo times (TEs), an approximately 28-47% improvement in lipid suppression was achieved with DIR compared to SIR. However, it also led to a loss of 37-43% in signal-to-noise ratio (SNR) for metabolites. Thus, SIR appears to be the better choice for suppressing lipid signals and maintaining metabolite sensitivity.
- In vivo MR spectroscopic imaging
- Inversion recovery
- Lipid relaxation
- Lipid suppression
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology