Comparison of in vitro potency of corticosteroids with ability to raise intraocular pressure

Herbert L. Cantrill; Paul F. Palmberg; Harry A. Zink; Stephen R. Waltman; Steven M. Podos; Bernard Becker

doi:10.1016/0002-9394(75)90687-X

Comparison of in vitro potency of corticosteroids with ability to raise intraocular pressure

Herbert L. Cantrill, Paul F. Palmberg, Harry A. Zink, Stephen R. Waltman, Steven M. Podos, Bernard Becker

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Corticosteroid inhibition of lymphocyte transformation was compared with ability to raise intraocular pressure in ten corticosteroid-sensitive patients. Dexamethasone used topically in the same concentration as fluorometholone had more than three times the ocular hypertensive effect but was similar in in vitro potency. A dissociation was also found for prednisolone and medrysone.

Original language	English (US)
Pages (from-to)	1012-1017
Number of pages	6
Journal	American journal of ophthalmology
Volume	79
Issue number	6
DOIs	https://doi.org/10.1016/0002-9394(75)90687-X
State	Published - Jun 1975
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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title = "Comparison of in vitro potency of corticosteroids with ability to raise intraocular pressure",

abstract = "Corticosteroid inhibition of lymphocyte transformation was compared with ability to raise intraocular pressure in ten corticosteroid-sensitive patients. Dexamethasone used topically in the same concentration as fluorometholone had more than three times the ocular hypertensive effect but was similar in in vitro potency. A dissociation was also found for prednisolone and medrysone.",

author = "Cantrill, {Herbert L.} and Palmberg, {Paul F.} and Zink, {Harry A.} and Waltman, {Stephen R.} and Podos, {Steven M.} and Bernard Becker",

year = "1975",

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AU - Cantrill, Herbert L.

AU - Palmberg, Paul F.

AU - Zink, Harry A.

AU - Waltman, Stephen R.

AU - Podos, Steven M.

AU - Becker, Bernard

PY - 1975/6

Y1 - 1975/6

N2 - Corticosteroid inhibition of lymphocyte transformation was compared with ability to raise intraocular pressure in ten corticosteroid-sensitive patients. Dexamethasone used topically in the same concentration as fluorometholone had more than three times the ocular hypertensive effect but was similar in in vitro potency. A dissociation was also found for prednisolone and medrysone.

AB - Corticosteroid inhibition of lymphocyte transformation was compared with ability to raise intraocular pressure in ten corticosteroid-sensitive patients. Dexamethasone used topically in the same concentration as fluorometholone had more than three times the ocular hypertensive effect but was similar in in vitro potency. A dissociation was also found for prednisolone and medrysone.

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Comparison of in vitro potency of corticosteroids with ability to raise intraocular pressure

Abstract

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