Comparison of hepatic resection and hepatic transplantation in the treatment of hepatocellular carcinoma among cirrhotic patients

Mohsen Shabahang, Dido Franceschi, Noriyo Yamashiki, Raj Reddy, Peter A. Pappas, Kuky Aviles, Sonia Flores, Andrea Chaparro, Joseph U. Levi, Danny Sleeman, Andreas G. Tzakis, Tomoaki Kato, David M. Levi, Alan S. Livingstone

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Background: The benefits of hepatic transplantation (HT) compared with hepatic resection (HR) in treating hepatocellular carcinoma (HCC) in patients with cirrhosis are controversial. The aim of this study was to compare the results of these therapeutic options. Methods: The charts of all patients with cirrhosis who underwent HR or HT for HCC between 1997 and 2000 were analyzed. Results: The cohort included 44 patients who underwent HR compared with 65 with HT. All patients in the HR group had Child's A disease, in contrast to the HT group, which included 23% Child's A and 77% Child's B and C patients. Whereas all HT patients spent at least three nights in the intensive care unit, 41% of the HR group never required critical care. Perioperative mortality was 7% in both groups. Pathologic analysis revealed T1/T2 disease in 43% of the HR group compared with 75% of the HT group. After 36 months of follow-up, there was no significant difference in overall survival (57% vs. 66%) or disease-free survival (36% vs. 66%) between the two groups. Conclusions: With overall survival and disease-free survival as the main outcomes, the results of HR versus HT are comparable in Child's A patients with HCC. In this patient subset, HR not only is an effective form of therapy, but is also associated with quicker recovery.

Original languageEnglish (US)
Pages (from-to)881-886
Number of pages6
JournalAnnals of Surgical Oncology
Volume9
Issue number9
DOIs
StatePublished - Nov 2002

Keywords

  • Cirrhotics
  • Hepatic resection
  • Hepatic transplantation
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Shabahang, M., Franceschi, D., Yamashiki, N., Reddy, R., Pappas, P. A., Aviles, K., Flores, S., Chaparro, A., Levi, J. U., Sleeman, D., Tzakis, A. G., Kato, T., Levi, D. M., & Livingstone, A. S. (2002). Comparison of hepatic resection and hepatic transplantation in the treatment of hepatocellular carcinoma among cirrhotic patients. Annals of Surgical Oncology, 9(9), 881-886. https://doi.org/10.1007/BF02557525