Comparison of early-onset neonatal sepsis caused by Escherichia coli and group B Streptococcus

Kathleen Mayor-Lynn, Víctor Hugo González-Quintero, Mary Jo O'Sullivan, Alan I. Hartstein, Sonia Roger, Madeline Tamayo

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objective: The purpose of this study was to compare maternal characteristics and neonatal morbidity and mortality rates that are associated with early-onset neonatal sepsis that is caused by group B Streptococcus and Escherichia coli. Study design: This was a retrospective review of newborn infants with a positive blood culture (and/or cerebrospinal fluid) that was positive for either E coli or group B Streptococcus during the first week of life. Data were abstracted from maternal and neonatal medical records. Results: Among 28,659 deliveries during the study period, 102 episodes of early-onset neonatal sepsis were identified, 61 of which were caused by group B Streptococcus and 41 of which were caused by E coli. E coli sepsis cases had a lower birth weight, a higher percentage with 5-minute Apgar score <7, and a longer stay in the hospital neonatal intensive care unit and required mechanical ventilation more frequently. Death after early-onset neonatal sepsis with E coli was also more frequent. Conclusion: Early-onset sepsis with E coli is associated with more morbidity and a higher mortality rate compared with early-onset group B Streptococcus.

Original languageEnglish (US)
Pages (from-to)1437-1439
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Issue number5 SPEC. ISS.
StatePublished - May 2005


  • Early-onset neonatal sepsis
  • Escherichia coli
  • Group B streptococcus

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)


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