Comparison of corneal thickness measured with optical coherence tomography, ultrasonic pachymetry, and a scanning slit method

Joseph Thomas, Jianhua Wang, Andrew M. Rollins, Julie Sturm

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22 Citations (Scopus)

Abstract

PURPOSE: To investigate the relationship between 1310-nm optical coherence tomography (OCT), an ultrasound pachymeter, and the Orbscan II (Bausch & Lomb, Rochester, NY) in corneal thickness measurements before and after LASIK. METHODS: Twenty-eight eyes of 14 patients with a mean age of 39.9±8.6 years underwent LASIK for correction of myopia with or without astigmatism. Central corneal thickness was measured with real-time 1310-nm OCT and Orbscan preoperatively and 1 day, 1 week, and 1 month postoperatively, and with an ultrasound pachymeter preoperatively and 1 month postoperatively. RESULTS: Measurements of corneal thickness by all instruments correlated well with one another pre- and postoperatively (r value range: 0.87 to 0.94, P<.05); however, there were significant differences among these methods (ANOVA: P<.005). Baseline readings for ultrasound and Orbscan were similar, as were readings 1 month postoperatively for OCT and Orbscan (P>.05). Thickness measured by OCT was thinner than for other instruments preoperatively (P<.005) and thicker than Orbscan postoperatively (P<.005). Significant corneal thinning (P<.001) was found with all study devices 1 day after laser ablation. Significant corneal thinning (P<.005) was found with OCT and Orbscan 1 week compared to 1 day postoperatively, and thickening (post hoc: P<.001) was evident at 1 month compared to 1 week postoperatively. CONCLUSIONS: Although the instruments correlated well in measuring corneal thickness after LASIK, there were significant differences. All instruments indicated corneal swelling and recovery during the first postoperative week and thickening at 1 month.

Original languageEnglish
Pages (from-to)671-678
Number of pages8
JournalJournal of Refractive Surgery
Volume22
Issue number7
StatePublished - Sep 1 2006

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Optical Coherence Tomography
Ultrasonics
Laser In Situ Keratomileusis
Corneal Pachymetry
Astigmatism
Myopia
Laser Therapy
Equipment and Supplies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Comparison of corneal thickness measured with optical coherence tomography, ultrasonic pachymetry, and a scanning slit method. / Thomas, Joseph; Wang, Jianhua; Rollins, Andrew M.; Sturm, Julie.

In: Journal of Refractive Surgery, Vol. 22, No. 7, 01.09.2006, p. 671-678.

Research output: Contribution to journalArticle

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N2 - PURPOSE: To investigate the relationship between 1310-nm optical coherence tomography (OCT), an ultrasound pachymeter, and the Orbscan II (Bausch & Lomb, Rochester, NY) in corneal thickness measurements before and after LASIK. METHODS: Twenty-eight eyes of 14 patients with a mean age of 39.9±8.6 years underwent LASIK for correction of myopia with or without astigmatism. Central corneal thickness was measured with real-time 1310-nm OCT and Orbscan preoperatively and 1 day, 1 week, and 1 month postoperatively, and with an ultrasound pachymeter preoperatively and 1 month postoperatively. RESULTS: Measurements of corneal thickness by all instruments correlated well with one another pre- and postoperatively (r value range: 0.87 to 0.94, P<.05); however, there were significant differences among these methods (ANOVA: P<.005). Baseline readings for ultrasound and Orbscan were similar, as were readings 1 month postoperatively for OCT and Orbscan (P>.05). Thickness measured by OCT was thinner than for other instruments preoperatively (P<.005) and thicker than Orbscan postoperatively (P<.005). Significant corneal thinning (P<.001) was found with all study devices 1 day after laser ablation. Significant corneal thinning (P<.005) was found with OCT and Orbscan 1 week compared to 1 day postoperatively, and thickening (post hoc: P<.001) was evident at 1 month compared to 1 week postoperatively. CONCLUSIONS: Although the instruments correlated well in measuring corneal thickness after LASIK, there were significant differences. All instruments indicated corneal swelling and recovery during the first postoperative week and thickening at 1 month.

AB - PURPOSE: To investigate the relationship between 1310-nm optical coherence tomography (OCT), an ultrasound pachymeter, and the Orbscan II (Bausch & Lomb, Rochester, NY) in corneal thickness measurements before and after LASIK. METHODS: Twenty-eight eyes of 14 patients with a mean age of 39.9±8.6 years underwent LASIK for correction of myopia with or without astigmatism. Central corneal thickness was measured with real-time 1310-nm OCT and Orbscan preoperatively and 1 day, 1 week, and 1 month postoperatively, and with an ultrasound pachymeter preoperatively and 1 month postoperatively. RESULTS: Measurements of corneal thickness by all instruments correlated well with one another pre- and postoperatively (r value range: 0.87 to 0.94, P<.05); however, there were significant differences among these methods (ANOVA: P<.005). Baseline readings for ultrasound and Orbscan were similar, as were readings 1 month postoperatively for OCT and Orbscan (P>.05). Thickness measured by OCT was thinner than for other instruments preoperatively (P<.005) and thicker than Orbscan postoperatively (P<.005). Significant corneal thinning (P<.001) was found with all study devices 1 day after laser ablation. Significant corneal thinning (P<.005) was found with OCT and Orbscan 1 week compared to 1 day postoperatively, and thickening (post hoc: P<.001) was evident at 1 month compared to 1 week postoperatively. CONCLUSIONS: Although the instruments correlated well in measuring corneal thickness after LASIK, there were significant differences. All instruments indicated corneal swelling and recovery during the first postoperative week and thickening at 1 month.

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