Comparison of chronic lymphocytic leukemia forms with different mutational status of immunoglobulin variable region genes

E. A. Nikitin, A. V. Pivnik, A. B. Sudarikov, G. M. Valova, N. G. Gabeeva, R. S. Samoilova, Dmitry V Ivanov, A. L. Melikyan, L. G. Kovaleva

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim. To compare forms of chronic lymphoid leukemia (CLL) regarding mutational status of immunoglobulin variable genes. Material and methods. We have compared clinical, prognostic and immunophenotypic data obtained on 25 cases with different mutational status of IgV genes. There were 10 patients in the mutated group (median age 49.2 years, male to female ratio=7:3), and 15 patients in unmutated group (median age 46.5, M:F=13:2). Results. Statistically significant differences were noted in overall survival and CD38 expression. 5-year overall survival in unmutated group was 35%, in mutated group 80% (p=0.07). In unmutated group CD38 was expressed on more than 50% of cells in 7 out of 14 patients, while in the mutated group in 0 of 8 patients (p=0.007). We noted high frequency of VH1-69 gene usage in unmutated group (7 of 15 patients), while in mutated group it was used in only 1 case of 10. Conclusion. We confirm the differences between groups of CLL with different mutational status of IgV genes. Highly restricted usage of VH-genes and CD38 expression possibly suggest that unmutated group also arises from antigen driven cells.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalTerapevticheskii Arkhiv
Volume72
Issue number7
StatePublished - Dec 1 2000
Externally publishedYes

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Immunoglobulin Variable Region
B-Cell Chronic Lymphocytic Leukemia
Lymphoid Leukemia
Genes
Age Groups
Immunoglobulin Genes
Survival
Gene Expression
Antigens

Keywords

  • Chronic lymphoid leukemia
  • Mutation status
  • Variable regions of immunoglobulin genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nikitin, E. A., Pivnik, A. V., Sudarikov, A. B., Valova, G. M., Gabeeva, N. G., Samoilova, R. S., ... Kovaleva, L. G. (2000). Comparison of chronic lymphocytic leukemia forms with different mutational status of immunoglobulin variable region genes. Terapevticheskii Arkhiv, 72(7), 52-56.

Comparison of chronic lymphocytic leukemia forms with different mutational status of immunoglobulin variable region genes. / Nikitin, E. A.; Pivnik, A. V.; Sudarikov, A. B.; Valova, G. M.; Gabeeva, N. G.; Samoilova, R. S.; Ivanov, Dmitry V; Melikyan, A. L.; Kovaleva, L. G.

In: Terapevticheskii Arkhiv, Vol. 72, No. 7, 01.12.2000, p. 52-56.

Research output: Contribution to journalArticle

Nikitin, EA, Pivnik, AV, Sudarikov, AB, Valova, GM, Gabeeva, NG, Samoilova, RS, Ivanov, DV, Melikyan, AL & Kovaleva, LG 2000, 'Comparison of chronic lymphocytic leukemia forms with different mutational status of immunoglobulin variable region genes', Terapevticheskii Arkhiv, vol. 72, no. 7, pp. 52-56.
Nikitin EA, Pivnik AV, Sudarikov AB, Valova GM, Gabeeva NG, Samoilova RS et al. Comparison of chronic lymphocytic leukemia forms with different mutational status of immunoglobulin variable region genes. Terapevticheskii Arkhiv. 2000 Dec 1;72(7):52-56.
Nikitin, E. A. ; Pivnik, A. V. ; Sudarikov, A. B. ; Valova, G. M. ; Gabeeva, N. G. ; Samoilova, R. S. ; Ivanov, Dmitry V ; Melikyan, A. L. ; Kovaleva, L. G. / Comparison of chronic lymphocytic leukemia forms with different mutational status of immunoglobulin variable region genes. In: Terapevticheskii Arkhiv. 2000 ; Vol. 72, No. 7. pp. 52-56.
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AU - Gabeeva, N. G.

AU - Samoilova, R. S.

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N2 - Aim. To compare forms of chronic lymphoid leukemia (CLL) regarding mutational status of immunoglobulin variable genes. Material and methods. We have compared clinical, prognostic and immunophenotypic data obtained on 25 cases with different mutational status of IgV genes. There were 10 patients in the mutated group (median age 49.2 years, male to female ratio=7:3), and 15 patients in unmutated group (median age 46.5, M:F=13:2). Results. Statistically significant differences were noted in overall survival and CD38 expression. 5-year overall survival in unmutated group was 35%, in mutated group 80% (p=0.07). In unmutated group CD38 was expressed on more than 50% of cells in 7 out of 14 patients, while in the mutated group in 0 of 8 patients (p=0.007). We noted high frequency of VH1-69 gene usage in unmutated group (7 of 15 patients), while in mutated group it was used in only 1 case of 10. Conclusion. We confirm the differences between groups of CLL with different mutational status of IgV genes. Highly restricted usage of VH-genes and CD38 expression possibly suggest that unmutated group also arises from antigen driven cells.

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