Comparison of changes in left ventricular gene expression profiles from different cardiac hypertrophy models in rats

Ping Li, Jin Liang Li, Xin Heng Feng, Zhao Ping Li, Feng Yin, Jie Yan, Rong Hou, Qi De Han, You Yi Zhang

Research output: Contribution to journalArticle

Abstract

To get insights into the principles of gene expression changes during cardiac hypertrophy, three rat cardiac hypertrophy models were prepared, i.e., suprarenal abdominal aortic stenosis (SRS), arterial-vein fistula (AVF) and continuous jugular vein infusion of norepinephrine (NEi). The cardiac function and structure were analyzed by echocardiograph as well as histological examination. Total RNA of left ventricles was extracted and gene expression profiles were analyzed by cDNA microarray. SRS and NEi induced concentric cardiac hypertrophy and AVF induced eccentric hypertrophy in rats, among which NEi caused obvious cardiac fibrosis. The changes of gene expression profiles were compared comprehensively across different pathologic cardiac hypertrophy models. While gene expression profiles of different cardiac hypertrophy models compared with pairs, parts of the genes involved were found overlapped, and mostly the gene expression changed in the same direction between two models, but some of them changed in the opposite directions. Expression levels of 19 genes were found changed across all cardiac hypertrophy models, and genes relatively regulated in a specific model was also found when comparison of all the three models was carried out. Novel clues for further study might derive from the results mentioned above, and some genes might be the marker genes of cardiac hypertrophy or the targets of therapy.

Original languageEnglish (US)
Pages (from-to)210-218
Number of pages9
JournalSheng li xue bao : [Acta physiologica Sinica]
Volume56
Issue number2
StatePublished - Apr 25 2004

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Li, P., Li, J. L., Feng, X. H., Li, Z. P., Yin, F., Yan, J., Hou, R., Han, Q. D., & Zhang, Y. Y. (2004). Comparison of changes in left ventricular gene expression profiles from different cardiac hypertrophy models in rats. Sheng li xue bao : [Acta physiologica Sinica], 56(2), 210-218.