Comparison of Carotid Intima-Media Thickness in Children and Adults With and Without Obesity: A Hysteresis Model

Nayely Garibay-Nieto, Brianda Areli Hernández-Morán, Eréndira Villanueva-Ortega, María José Garcés-Hernández, Karen Pedraza-Escudero, América Arroyo-Valerio, César Pedraza-Helvert, Arturo Herrera-Rosas, Estibalitz Laresgoiti-Servitje, Mireya León-Hernández, Neyla Baltazar-López, Joselin Hernández-Ruíz, Fabiola Serratos-Canales, Gloria Queipo-García, Sarah Elizabeth Messiah, Srinivas Mummidi, Juan Carlos López-Alvarenga

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To describe a third-degree polynomial function (hysteresis) of the effect size of age, obesity, and insulin sensitivity over the carotid intima-media thickness (c-IMT), in the pediatric and adult groups. Methods: A quasi-experimental study with fixed factor analysis of age (children aged 8-12 years, n = 73; adults aged 21-45 years, n = 82) and obesity (yes, n = 76; no, n = 79) was conducted to analyze the effect on the c-IMT and Matsuda insulin sensitivity index values. This quasi-experimental design was analyzed with robust regression modeling. Results: The additive effect of obesity, independent of age, was evident in the case of the c-IMT values. There was no interaction effect, but a significant difference between participants with normal weight and those with obesity was found (P < .0001). The difference between adults and children was also significant, but the effect size was smaller. A model was created based on age, Tanner stage, and obesity using the c-IMT and Matsuda insulin sensitivity index values. A linear function fit as R2, and the cubic function estimated parameters like a polynomial model. Conclusion: This practical study design showed that children with obesity displayed the same levels of carotid intima-media abnormalities as adults with obesity. The polynomial shape of the model suggests potentially poor outcomes that resemble the hysteresis process and may predict chronic cardiometabolic events during early adulthood.

Original languageEnglish (US)
JournalEndocrine Practice
DOIs
StateAccepted/In press - 2021

Keywords

  • adults
  • children
  • hysteresis
  • insulin resistance
  • obesity
  • vascular damage

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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