Comparison of buspirone and diazepam in generalized anxiety disorder

A. F. Jacobson, R. D. Dominguez, B. J. Goldstein, R. M. Steinbook

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

A total of 66 outpatients meeting Diagnostic and Statistical Manual (DSM-III) criteria for generalized anxiety disorder began treatment in a randomized double-blind study that compared the efficacy and safety of buspirone and diazepam. Thirty-nine outpatients completed the 4-week trial. Both drugs were administered in a 1:1 dosage ratio; the daily prescribed dose did not exceed 40 mg. The mean daily dose of buspirone prescribed throughout the study was significantly higher than that of diazepam. Diazepam had a significantly earlier onset of efficacy than buspirone, although both drugs were equivalent after 4 weeks of treatment. Adverse reactions were more frequent in the diazepam group. Total scores from the Hamilton anxiety scale and physician's global ratings show that diazepam was significantly superior to buspirone during the initial 2 weeks of treatment. These findings are further corroborated by the results of patients' self-rated scales.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalPharmacotherapy
Volume5
Issue number5
StatePublished - Dec 1 1985
Externally publishedYes

Fingerprint

Buspirone
Diazepam
Anxiety Disorders
Outpatients
Double-Blind Method
Diagnostic and Statistical Manual of Mental Disorders
Pharmaceutical Preparations
Therapeutics
Anxiety
Physicians
Safety

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Jacobson, A. F., Dominguez, R. D., Goldstein, B. J., & Steinbook, R. M. (1985). Comparison of buspirone and diazepam in generalized anxiety disorder. Pharmacotherapy, 5(5), 290-296.

Comparison of buspirone and diazepam in generalized anxiety disorder. / Jacobson, A. F.; Dominguez, R. D.; Goldstein, B. J.; Steinbook, R. M.

In: Pharmacotherapy, Vol. 5, No. 5, 01.12.1985, p. 290-296.

Research output: Contribution to journalArticle

Jacobson, AF, Dominguez, RD, Goldstein, BJ & Steinbook, RM 1985, 'Comparison of buspirone and diazepam in generalized anxiety disorder', Pharmacotherapy, vol. 5, no. 5, pp. 290-296.
Jacobson AF, Dominguez RD, Goldstein BJ, Steinbook RM. Comparison of buspirone and diazepam in generalized anxiety disorder. Pharmacotherapy. 1985 Dec 1;5(5):290-296.
Jacobson, A. F. ; Dominguez, R. D. ; Goldstein, B. J. ; Steinbook, R. M. / Comparison of buspirone and diazepam in generalized anxiety disorder. In: Pharmacotherapy. 1985 ; Vol. 5, No. 5. pp. 290-296.
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