We report a prospective, randomized, single-blinded trial comparing immunogenicity of rapid (0, 1, and 2 months) versus standard schedule (0, 1, 6 months) hepatitis B vaccinations of healthy adults with recombinant hepatitis B vaccine (Engerix-B, 20 μg i.m.) Volunteers (230 of 234) negative to hepatitis B were randomized and completed the study. Groups were similar in age, weight, race, and obesity rate, but the rapid schedule group had more women. Both groups reached ≥100 mIU/mL at a similar rate, but a higher seroprotection rate at ≥500 mIU/mL was reached by the standard schedule. No demographic variables influenced the effect of dose schedule on anti- hepatitis B titer. We conclude that rapid schedule vaccination gives a rate that is quicker than, and identical to, the rate of seroprotection of the standard schedule vaccination.
|Original language||English (US)|
|Number of pages||5|
|Journal||American Journal of Gastroenterology|
|State||Published - Jan 1 1996|
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