Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging

Bernard J. Villegas, Robert Hendel, Seth T. Dahlberg, Brenda A. McSherry, Jeffrey A. Leppo

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 μg/kg/min) was performed in 11 subjects. Subjects reported more side effects during the 6-minute infusion protocol (p < 0.05). Hemodynamic changes were not different during either infusion duration. All dysrhythmias began within 2 minutes and therefore the duration of the infusion did not influence their occurrence. Segmental comparison of the stress images demonstrated an 89% agreement. Delayed scans demonstrated a 79% agreement. There was a higher incidence of redistribution following the 6-minute infusion (p = 0.014). We conclude that when side effects necessitate the discontinuation of a 6-minute adenosine infusion, a diagnostic test can still be achieved if 2 to 3 minutes of adenosine have been administered before the thallium injection; however, the amount of viable myocardium may be underestimated.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalAmerican Heart Journal
Volume126
Issue number1
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Myocardial Perfusion Imaging
Thallium
Adenosine
Routine Diagnostic Tests
Coronary Artery Disease
Myocardium
Hemodynamics
Injections
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging. / Villegas, Bernard J.; Hendel, Robert; Dahlberg, Seth T.; McSherry, Brenda A.; Leppo, Jeffrey A.

In: American Heart Journal, Vol. 126, No. 1, 01.01.1993, p. 103-107.

Research output: Contribution to journalArticle

Villegas, Bernard J. ; Hendel, Robert ; Dahlberg, Seth T. ; McSherry, Brenda A. ; Leppo, Jeffrey A. / Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging. In: American Heart Journal. 1993 ; Vol. 126, No. 1. pp. 103-107.
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