Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging

Bernard J. Villegas, Robert C. Hendel, Seth T. Dahlberg, Brenda A. McSherry, Jeffrey A. Leppo

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 μg/kg/min) was performed in 11 subjects. Subjects reported more side effects during the 6-minute infusion protocol (p < 0.05). Hemodynamic changes were not different during either infusion duration. All dysrhythmias began within 2 minutes and therefore the duration of the infusion did not influence their occurrence. Segmental comparison of the stress images demonstrated an 89% agreement. Delayed scans demonstrated a 79% agreement. There was a higher incidence of redistribution following the 6-minute infusion (p = 0.014). We conclude that when side effects necessitate the discontinuation of a 6-minute adenosine infusion, a diagnostic test can still be achieved if 2 to 3 minutes of adenosine have been administered before the thallium injection; however, the amount of viable myocardium may be underestimated.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalAmerican Heart Journal
Issue number1
StatePublished - Jul 1993
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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