@article{5414dce0161948fd8f57923c9610c8c3,
title = "Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging",
abstract = "Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 μg/kg/min) was performed in 11 subjects. Subjects reported more side effects during the 6-minute infusion protocol (p < 0.05). Hemodynamic changes were not different during either infusion duration. All dysrhythmias began within 2 minutes and therefore the duration of the infusion did not influence their occurrence. Segmental comparison of the stress images demonstrated an 89% agreement. Delayed scans demonstrated a 79% agreement. There was a higher incidence of redistribution following the 6-minute infusion (p = 0.014). We conclude that when side effects necessitate the discontinuation of a 6-minute adenosine infusion, a diagnostic test can still be achieved if 2 to 3 minutes of adenosine have been administered before the thallium injection; however, the amount of viable myocardium may be underestimated.",
author = "Villegas, {Bernard J.} and Hendel, {Robert C.} and Dahlberg, {Seth T.} and McSherry, {Brenda A.} and Leppo, {Jeffrey A.}",
note = "Funding Information: From the Myocardial Isotope Research Laboratory, University of Massachusetts Medical Center. Supported in part by National Institutes ot Health Research Grant ROl HL 34199, Effect of Flow and Metabolic Changes in Cardiac Isotopes; by American Heart Association Grant-in-Aid No. 89-978, Cardiac Imaging and Transport of Tracers for Injury and Flow; and by Medco Research, Inc. Received for publication Nov. 25, 1992; accepted Jan. 8, 1993. Reprint requests: Bernard J. Villegas, MD, Department of Nuclear Medicine, University of Massachusetts Medical Center, 55 Lake Ave. North, Worcester, MA 01656. Copyright {\textregistered} 1993 by Mosby-Year Book, Inc. 0002-8703/93/31.00 + .10 4/1/46387 Coronary artery disease can be detected with vasodilators by provoking a disparity in regional coronary perfusion that can then be visualized by thallium-201 (2°^T1) imaging. Dipyridamole has been extensively investigated for this procedure and can both detect^' ^ and stratify^'* risk in patients with coronary artery disease. Since the mechanism of hyperemia with dipyridamole involves an increase in endogenous levels of adenosine, recent investigations have focused on the use of intravenous adenosine alone.",
year = "1993",
month = jul,
doi = "10.1016/S0002-8703(07)80015-9",
language = "English (US)",
volume = "126",
pages = "103--107",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "1",
}