Abstract
Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 μg/kg/min) was performed in 11 subjects. Subjects reported more side effects during the 6-minute infusion protocol (p < 0.05). Hemodynamic changes were not different during either infusion duration. All dysrhythmias began within 2 minutes and therefore the duration of the infusion did not influence their occurrence. Segmental comparison of the stress images demonstrated an 89% agreement. Delayed scans demonstrated a 79% agreement. There was a higher incidence of redistribution following the 6-minute infusion (p = 0.014). We conclude that when side effects necessitate the discontinuation of a 6-minute adenosine infusion, a diagnostic test can still be achieved if 2 to 3 minutes of adenosine have been administered before the thallium injection; however, the amount of viable myocardium may be underestimated.
| Original language | English |
|---|---|
| Pages (from-to) | 103-107 |
| Number of pages | 5 |
| Journal | American Heart Journal |
| Volume | 126 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging. / Villegas, Bernard J.; Hendel, Robert; Dahlberg, Seth T.; McSherry, Brenda A.; Leppo, Jeffrey A.
In: American Heart Journal, Vol. 126, No. 1, 01.01.1993, p. 103-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging
AU - Villegas, Bernard J.
AU - Hendel, Robert
AU - Dahlberg, Seth T.
AU - McSherry, Brenda A.
AU - Leppo, Jeffrey A.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 μg/kg/min) was performed in 11 subjects. Subjects reported more side effects during the 6-minute infusion protocol (p < 0.05). Hemodynamic changes were not different during either infusion duration. All dysrhythmias began within 2 minutes and therefore the duration of the infusion did not influence their occurrence. Segmental comparison of the stress images demonstrated an 89% agreement. Delayed scans demonstrated a 79% agreement. There was a higher incidence of redistribution following the 6-minute infusion (p = 0.014). We conclude that when side effects necessitate the discontinuation of a 6-minute adenosine infusion, a diagnostic test can still be achieved if 2 to 3 minutes of adenosine have been administered before the thallium injection; however, the amount of viable myocardium may be underestimated.
AB - Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 μg/kg/min) was performed in 11 subjects. Subjects reported more side effects during the 6-minute infusion protocol (p < 0.05). Hemodynamic changes were not different during either infusion duration. All dysrhythmias began within 2 minutes and therefore the duration of the infusion did not influence their occurrence. Segmental comparison of the stress images demonstrated an 89% agreement. Delayed scans demonstrated a 79% agreement. There was a higher incidence of redistribution following the 6-minute infusion (p = 0.014). We conclude that when side effects necessitate the discontinuation of a 6-minute adenosine infusion, a diagnostic test can still be achieved if 2 to 3 minutes of adenosine have been administered before the thallium injection; however, the amount of viable myocardium may be underestimated.
UR - http://www.scopus.com/inward/record.url?scp=0027208072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027208072&partnerID=8YFLogxK
U2 - 10.1016/S0002-8703(07)80015-9
DO - 10.1016/S0002-8703(07)80015-9
M3 - Article
C2 - 8322650
AN - SCOPUS:0027208072
VL - 126
SP - 103
EP - 107
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1
ER -