Comparison between spectral-domain and swept-source optical coherence tomography angiographic imaging of choroidal neovascularization

Andrew R. Miller, Luiz Roisman, Qinqin Zhang, Fang Zheng, Joao Rafael de Oliveira Dias, Zohar Yehoshua, Karen B. Schaal, William J Feuer, Giovanni Gregori, Zhongdi Chu, Chieh Li Chen, Sophie Kubach, Lin An, Paul F. Stetson, Mary K. Durbin, Ruikang K. Wang, Philip J Rosenfeld

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

PURPOSE. The purpose of this study was to compare imaging of choroidal neovascularization (CNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA). METHODS. Optical coherence tomography angiography was performed using a 100-kHz SS-OCT instrument and a 68-kHz SD-OCTA instrument (Carl Zeiss Meditec, Inc.). Both 3 × 3- and 6 × 6-mm2 scans were obtained on both instruments. The 3 × 3-mm2 SS-OCTA scans consisted of 300 A-scans per B-scan at 300 B-scan positions, and the SD-OCTA scans consisted of 245 A-scans at 245 B-scan positions. The 6 × 6-mm2 SS-OCTA scans consisted of 420 Ascans per B-scan at 420 B-scan positions, and the SD-OCTA scans consisted of 350 A-scans and 350 B-scan positions. B-scans were repeated four times at each position in the 3 × 3-mm2 scans and twice in the 6 × 6-mm2 scans. Choroidal neovascularization was excluded if not fully contained within the 3 × 3-mm2 scans. The same algorithm was used to detect CNV on both instruments. Two graders outlined the CNV, and the lesion areas were compared between instruments. RESULTS. Twenty-seven consecutive eyes from 23 patients were analyzed. For the 3 × 3-mm2 scans, the mean lesion areas for the SS-OCTA and SD-OCTA instruments were 1.17 and 1.01 mm2, respectively (P = 0.047). For the 6 × 6-mm2 scans, the mean lesion areas for the SS-OCTA and SD-OCTA instruments were 1.24 and 0.74 mm2 (P = 0.003). CONCLUSIONS. The areas of CNV tended to be larger when imaged with SS-OCTA than with SD-OCTA, and this difference was greater for the 6 × 6-mm2 scans.

Original languageEnglish (US)
Pages (from-to)1499-1505
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume58
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • Choroidal neovascularization
  • Neovascular AMD
  • OCTA
  • Optical coherence tomography angiography
  • Spectral-domain OCTA
  • Swept-source OCTA

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Miller, A. R., Roisman, L., Zhang, Q., Zheng, F., Rafael de Oliveira Dias, J., Yehoshua, Z., Schaal, K. B., Feuer, W. J., Gregori, G., Chu, Z., Chen, C. L., Kubach, S., An, L., Stetson, P. F., Durbin, M. K., Wang, R. K., & Rosenfeld, P. J. (2017). Comparison between spectral-domain and swept-source optical coherence tomography angiographic imaging of choroidal neovascularization. Investigative Ophthalmology and Visual Science, 58(3), 1499-1505. https://doi.org/10.1167/iovs.16-20969